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Human dendritic cell deficiency: the missing ID?

Lookup NU author(s): Professor Matthew CollinORCiD, Dr Venetia BigleyORCiD, Professor Muzlifah Haniffa, Professor Sophie HambletonORCiD


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Animal models and human in vitro systems indicate that dendritic cells (DCs) have a crucial role in priming naive T cells, but just how important are they in the intact human? Recent descriptions of human DC deficiency have begun to shed light on this question and to illuminate other puzzles of human DC biology, including their haematopoietic origin, developmental regulation and homeostatic equilibrium with other leukocytes. In this Review, we explore the recently described DC deficiency syndromes, discussing what these have taught us with regard to DC function in humans and the important issues that remain unsolved.

Publication metadata

Author(s): Collin M, Bigley V, Haniffa M, Hambleton S

Publication type: Review

Publication status: Published

Journal: Nature Reviews Immunology

Year: 2011

Volume: 11

Issue: 9

Pages: 575-583

Print publication date: 01/09/2011

ISSN (print): 1474-1733

ISSN (electronic): 1474-1741



DOI: 10.1038/nri3046