Publications by Dr Venetia Bigley - ePrints

Browsing publications by Dr Venetia Bigley.

Newcastle Authors	Title	Year
Dr Christo Tsilifis Dr Suzanne Elcombe Dr Venetia Bigley Dr Alexandra Laberko Professor Andrew Gennery et al.	Hematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: A European Society for Blood and Marrow Transplantation Inborn Errors Working Party study	2024
Dr Alexandra Laberko Dr Venetia Bigley Dr Suzanne Elcombe Professor Andrew Gennery	An International Survey of Allogeneic Hematopoietic Cell Transplantation for X-Linked Agammaglobulinemia	2023
Dr Venetia Bigley	Guidelines for mouse and human DC generation	2023
Dr Callum Wright Dr Clare Lendrem Dr Amy Publicover Louise Duncan Dr Venetia Bigley et al.	Host versus graft HLA-DP1 mismatching promotes graft versus host disease	2023
Dr Venetia Bigley	Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	2023
Dr Paul Milne Dr Simon Bomken Maymoon Madkhali Jamie Macdonald Dr Preeti Singh et al.	Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis	2023
Tom Pither Dr Lu Wang Lucy Bates Dr Morvern Morrison Catriona Charlton et al.	Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model	2023
Dr Florian Gothe Catherine Hatton Angela Grainger Dr Venetia Bigley Dr Joanna Perthen et al.	A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis	2022
Dr Suzanne Elcombe Dr Christopher Duncan Dr Venetia Bigley	Allogeneic haematopoietic stem cell transplantation for VEXAS syndrome: UK experience	2022
Dr Ricky Tirtakusuma Dr Katarzyna Szoltysek Professor Vasily Grinev Dr Sirintra Nakjang Dr Daniel Williamson et al.	Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia	2022
Professor Andrew Gennery Dr Venetia Bigley Professor Mary Slatter	Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study	2022
Dr Venetia Bigley	PAMI Syndrome: Two Cases of an Autoinflammatory Disease with an ALPS-Like Phenotype	2022
Dr Preeti Singh Maninder Heer Dr Anastasia Resteu Dr Aneta Mikulasova Dr Mojgan Reza et al.	GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1	2021
Professor Matthew Collin Dr Venetia Bigley	Many Langerhans make light work of skin immunity	2021
Dr Urszula Cytlak-Chaudhuri Dr Anastasia Resteu Sarah Pagan Dr Kile Green Dr Paul Milne et al.	Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans	2020
Dr Laura Jardine Dr Urszula Cytlak-Chaudhuri Dr Merry Gunawan Dr Gary Reynolds Dr Kile Green et al.	Donor monocyte-derived macrophages promote human acute graft-versus-host disease	2020
Dr Venetia Bigley Professor Matthew Collin	Insights from Patients with Dendritic Cell Immunodeficiency	2020
Dr Venetia Bigley	Subsets of CD1c⁺DCs: Dendritic Cell Versus Monocyte Lineage	2020
Dr Venetia Bigley Dr Urszula Cytlak-Chaudhuri Professor Matthew Collin	Human dendritic cell immunodeficiencies	2019
Dr Paul Milne Dr Venetia Bigley Dr Amy Publicover Sarah Pagan Dr Helen Marr et al.	Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia	2019
Dr Katherine Sturgess Dr Rachel Dickinson Professor Andrew Gennery Professor Andrew Cant Professor Graham Jackson et al.	In vivo T-depleted reduced intensity transplantation for GATA2-related immune dysfunction.	2018
Dr Urszula Cytlak-Chaudhuri Dr Venetia Bigley	A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects	2018
Dr Venetia Bigley Dr Urszula Cytlak-Chaudhuri Dr Laura Jardine Dr Kile Green Dr Merry Gunawan et al.	Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation	2018
Professor Matthew Collin Dr Venetia Bigley	Human dendritic cell subsets: an update	2018
Dr Urszula Cytlak-Chaudhuri Dr Anastasia Resteu Dr Tom Altmann Professor Andrew Gennery Professor Graham Jackson et al.	Ikaros family zinc finger 1 regulates dendritic cell development and function in humans	2018
Dr Urszula Cytlak-Chaudhuri Dr Anastasia Resteu Professor Matthew Collin Dr Venetia Bigley	Notch signaling facilitates in vitro generation of cross-presenting classical dendritic cells	2018
Dr Venetia Bigley	Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency.	2018
Dr Venetia Bigley Dr Rachel Dickinson Professor Matthew Collin	Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells	2017
Dr Venetia Bigley Professor Matthew Collin Professor Andrew Cant	Biallelic mutations in IRF8 impair human NK cell maturation and function	2017
Dr Paul Milne Dr Venetia Bigley Dr Christopher Bacon Dr Naomi McGovern Dr Simon Bomken et al.	Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults	2017
Dr Naomi McGovern Dr Xiao Wang Dr Venetia Bigley Professor Matthew Collin Professor Muzlifah Haniffa et al.	Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2	2017
Dr Kile Green Dr Kim Pearce Dr Laura Jardine Dr Venetia Bigley Professor Graham Jackson et al.	Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts	2017
Dr Paul Milne Dr Venetia Bigley Professor Matthew Collin	Targeted treatment of brainstem neurohistiocytosis guided by urinary cell-free DNA	2017
Amit Patel Dr Venetia Bigley	The fate and lifespan of human monocyte subsets in steady state and systemic inflammation	2017
Dr Venetia Bigley Professor Matthew Collin	Dendritic cell analysis in primary immunodeficiency	2016
Kile Green Dr Laura Jopson Dr Ben Barron-Millar Barbara Innes Sarah Pagan et al.	Early Molecular Stratification of High-risk Primary Biliary Cholangitis	2016
Professor Matthew Collin Dr Venetia Bigley	Monocyte, macrophage, and dendritic cell development: The human perspective	2016
Dr Venetia Bigley Dr Simon Bomken Professor Matthew Collin	National Web-Based Meetings Help to Identify Histiocytosis Patients with Refractory Disease or Sequelae who Need Individualised or Novel Treatment Strategies	2016
Dr Venetia Bigley Professor Matthew Collin	Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease	2016
Professor Matthew Collin Dr Paul Milne Dr Venetia Bigley Professor Muzlifah Haniffa	The Hematopoietic Origin of Adult Histiocytosis	2016
Dr Sara Mannurita Dr Venetia Bigley Professor Matthew Collin Dr Eleonora Gambineri	Timely follow-up of a GATA2 deficiency patient allows successful treatment	2016
Dr Gary Reynolds Dr Paul Milne Dr Venetia Bigley Professor Matthew Collin Professor John Isaacs et al.	Use of the dendritic cell marker, B and T lymphocyte attenuator, to identify functionally distinct subsets of human CD1c+ dendritic cells	2016
Dr Laura Jardine Dr Venetia Bigley Dr Kim Pearce Dr Alison Dickinson Professor Graham Jackson et al.	A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants	2015
Dr Jane Salotti Dr Venetia Bigley Dr Katrina Wood Professor Matthew Collin Dr Kevin Windebank et al.	A Regional Study of Adults with Histiocytic Disorders in Northeast England	2015
Dr Venetia Bigley Professor Matthew Collin	Autoimmune hepatitis with T-regulatory cell deficiency in the context of GATA-2 dysfunction: A novel single gene association	2015
Dr Paul Milne Dr Venetia Bigley Dr Merry Gunawan Professor Muzlifah Haniffa Professor Matthew Collin et al.	CD1c⁺ blood dendritic cells have Langerhans cell potential	2015
Professor Matthew Collin Dr Venetia Bigley	Cell(s) of Origin of Langerhans Cell Histiocytosis	2015
Professor Matthew Collin Dr Rachel Dickinson Dr Venetia Bigley	Haematopoietic and immune defects associated with GATA2 mutation	2015
Professor Muzlifah Haniffa Dr Venetia Bigley Professor Matthew Collin	Human mononuclear phagocyte system reunited	2015
Dr Venetia Bigley Dr Naomi McGovern Dr Paul Milne Dr Rachel Dickinson Sarah Pagan et al.	Langerin-expressing dendritic cells in human tissues are related to CD1c⁺ dendritic cells and distinct from Langerhans cells and CD₁₄₁^high XCR1⁺ dendritic cells	2015
Dr Paul Milne Professor Matthew Collin Dr Venetia Bigley Dr Christopher Bacon Dr Naomi McGovern et al.	Mapping the BRAFV600E Hematopoietic Clone of Adult Multi-System Langerhans Cell Histiocytosis	2015
Dr Mario Abinun Professor Roderick Skinner Dr Venetia Bigley	Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases	2015
Professor Matthew Collin Dr Paul Milne Dr Venetia Bigley Professor Muzlifah Haniffa	Studies on the Pathway of Differentiation of LCH Cells	2015
Dr Jane Salotti Dr Venetia Bigley Professor Matthew Collin	An Epidemiological Survey of Adults with Histiocytic Disorders in the Northeast Region of the UK	2014
Dr Venetia Bigley Professor Matthew Collin	BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups	2014
Dr Paul Milne Dr Venetia Bigley Dr Merry Gunawan Professor Muzlifah Haniffa Professor Matthew Collin et al.	CD1c+ blood dendritic cells have Langerhans cell potential	2014
Dr Venetia Bigley Professor Muzlifah Haniffa Professor Sophie Hambleton	Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8^K108E mutation	2014
Dr Naomi McGovern Dr Merry Gunawan Dr Laura Jardine Dr Elizabeth Poyner Kile Green et al.	Human Dermal CD14⁺ Cells Are a Transient Population of Monocyte-Derived Macrophages	2014
Dr Venetia Bigley Dr Rachel Dickinson Dr Laura Jardine Dr Paul Milne Dr Helen Griffin et al.	Human SHP-1 Mutation Causes an Autoinflammatory and Immunodeficiency Phenotype	2014
Dr Naomi McGovern Dr Merry Gunawan Dr Laura Jardine Dr Elizabeth Poyner Dr Kile Green et al.	Human tissue mononuclear phagocyte system revisited	2014
Dr Rachel Dickinson Dr Paul Milne Sarah Pagan Dr Venetia Bigley Professor Matthew Collin et al.	Reduced GATA-2 expression in individuals with DCML deficiency	2014
Professor Graham Jackson Dr Venetia Bigley Professor Matthew Collin	T cell depleted reduced intensity transplantation is effective for patients with GATA2 mutation and severe infections or respiratory compromise	2014
Dr Rachel Dickinson Paul Milne Dr Laura Jardine Dr Naomi McGovern Dr Sharon Cookson et al.	The evolution of cellular deficiency in GATA2 mutation	2014
Dr Kile Green Dr Laura Jardine Dr Kim Pearce Dr Venetia Bigley Professor Graham Jackson et al.	Defining The Optimal Dose Of Alemtuzumab In Unrelated Donor Reduced Intensity Allografts: A UK Retrospective Study	2013
Dr Naomi McGovern Dr Kevin Windebank Sarah Pagan Dr Venetia Bigley Professor Matthew Collin et al.	Microanatomical dissection of the human dermis: The relationship between antigen presenting cells, lymphatic and blood vessels	2013
Dr Laura Jardine Ashley Ames-Draycott Sarah Pagan Dr Sharon Cookson Dr Gavin Spickett et al.	Rapid detection of dendritic cell and monocyte disorders using CD4 as a lineage marker of the human peripheral blood antigen-presenting cell compartment	2013
Dr Laura Jardine Professor Sophie Hambleton Dr Venetia Bigley Sarah Pagan Dr Xiao Wang et al.	Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands	2013
Dr Eleonora Gambineri Dr Sara Mannurita Dr Venetia Bigley Professor Matthew Collin	Timely Follow-up of a GATA2 Deficiency Patient as Predictor of Successful Treatment	2013
Dr Kevin Windebank Dr Venetia Bigley Professor Muzlifah Haniffa Professor Matthew Collin	Treatment of Adult LCH with Subcutaneous Cladribine	2013
Dr Thomas Huegle Dr Steven O'Reilly Rachel Simpson Dr Venetia Bigley Professor Matthew Collin et al.	Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts	2013
Professor Matthew Collin Dr Rachel Dickinson Professor Muzlifah Haniffa Dr Naomi McGovern Dr Helen Griffin et al.	Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation	2012
Dr Venetia Bigley Dr Rachel Dickinson Professor Andrew Gennery Dr Helen Griffin Professor Muzlifah Haniffa et al.	Human dendritic cell deficiency	2012
Professor Muzlifah Haniffa Dr Venetia Bigley Dr Naomi McGovern Dr Xiao Wang Sarah Pagan et al.	Human Tissues Contain CD141^hiCross-Presenting Dendritic Cells with Functional Homology to Mouse CD103⁺ Nonlymphoid Dendritic Cells	2012
Professor Muzlifah Haniffa Dr Venetia Bigley Dr Naomi McGovern Dr Xiao Wang Professor Matthew Collin et al.	Identification of a novel cross-presenting migratory dendritic cell in the human skin: the key cell for rational vaccine strategies	2012
Dr Naomi McGovern Dr Rachel Dickinson Dr Venetia Bigley Professor Matthew Collin	Identification of GATA-2 mutations using a simple screening procedure in patients with Papilloma virus infections	2012
Professor Muzlifah Haniffa Dr Venetia Bigley Dr Naomi McGovern Dr Xiao Wang Professor Matthew Collin et al.	Identification of the human cross-presenting migratory dendritic cell	2012
Professor Muzlifah Haniffa Dr Venetia Bigley Dr Naomi McGovern Professor Matthew Collin	Identification of the human cross-presenting migratory dendritic cell and harmonization of the functional classification of human and mouse dendritic cells	2012
Dr Katherine Sturgess Professor Mary Slatter Dr Venetia Bigley Dr Rachel Dickinson Professor Muzlifah Haniffa et al.	Reduced-intensity haematopoietic stem cell transplant rescues immune function and corrects pulmonary alveolar proteinosis in DCML deficiency/GATA 2 mutation	2012
Dr Steven O'Reilly Dr Venetia Bigley Professor Matthew Collin Dr Anja Krippner-Heidenreich Professor Jaap van Laar et al.	Tumor necrosis factor-alpha co-activated T-cells support a profibrotic cytokine milieu on cost of IL-10 expression in patients with systemic sclerosis	2012
Professor Sophie Hambleton Dr Venetia Bigley Professor Muzlifah Haniffa Dr Christopher Bacon Professor Andrew Cant et al.	IRF8 Mutations and Human Dendritic-Cell Immunodeficiency	2011
Professor Muzlifah Haniffa Dr Venetia Bigley Dr Naomi McGovern Dr Xiao Wang Hongwei Zhou et al.	CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation	2011
Dr Venetia Bigley Professor Matthew Collin	Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome	2011
Dr Venetia Bigley Professor Muzlifah Haniffa Dr Xiao Wang Dr Rachel Dickinson Dr Naomi McGovern et al.	Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation	2011
Dr Rachel Dickinson Dr Helen Griffin Dr Venetia Bigley Dr Louise Reynard Raf Hussain et al.	Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency	2011
Dr Rachel Dickinson Dr Venetia Bigley Dr Helen Griffin Professor Jeremy Lakey Dr Naomi McGovern et al.	Human dendritic cell deficiency is caused by GATA-2 mutation	2011
Professor Matthew Collin Dr Venetia Bigley Professor Muzlifah Haniffa Professor Sophie Hambleton	Human dendritic cell deficiency: the missing ID?	2011
Dr Naomi McGovern Dr Venetia Bigley Professor Muzlifah Haniffa Dr Xiao Wang Dr Rachel Dickinson et al.	Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis	2011
Dr Katherine Sturgess Professor Mary Slatter Dr Venetia Bigley Professor Muzlifah Haniffa Dr Xiao Wang et al.	Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation	2011
Dr Venetia Bigley Dr Xiao Wang Dr Rachel Dickinson Dr Naomi McGovern Sarah Pagan et al.	The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency	2011
Dr Thomas Huegle Dr Anja Krippner-Heidenreich Rachel Simpson Dr Steven O'Reilly Dr Venetia Bigley et al.	Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta	2011
Dr Wei Cope Dr Laura Jardine Dr Venetia Bigley Sarah Pagan Brie Turner et al.	A retrospective study of alemtuzumab level, t-cell chimerism and graft-versus-host disease using intermediate dose alemtuzumab for matched related and matched unrelated reduced-intensity transplantation	2010
Dr Thomas Huegle Dr Venetia Bigley Professor Jaap Van Laar	Analysis of mononuclear cell subsets in dermis and blood of patients with systemic sclerosis by multicolour flow cytometry	2010
Dr Venetia Bigley Dr Laura Jardine Professor Matthew Collin	Connecting the dots: monocyte/DC and NK subsets in human peripheral blood	2010
Dr Venetia Bigley Dr Clare Morgan Professor Matthew Collin Dr James Lordan	Pulmonary alveolar proteinosis due to monocytopenia: lung transplant or haematopoeitic stem cell transplant? [abstract]	2010
Dr Rachel Dickinson Dr Venetia Bigley Professor Matthew Collin	The Equilibration of Peripheral Blood and Tissue CD3+T Cell Engraftment Is Influenced by Graft Versus Host Disease Following Reduced Intensity Conditioning Stem Cell Transplantation.	2010
Professor Muzlifah Haniffa Dr Venetia Bigley Sarah Pagan Dr Xiao Wang Professor Matthew Collin et al.	The persistence of recipient antigen presenting cells after stem cell transplantation in humans	2010
Dr Venetia Bigley Sarah Pagan Brie Turner Professor Graham Jackson Professor Anne Dickinson et al.	A Retrospective Study of Alemtuzumab Level, T Cell Chimerism and Graft Versus Host Disease Using Intermediate Dose Alemtuzumab for Matched Related and Matched Unrelated Reduced Intensity Transplantation.	2009
Professor Muzlifah Haniffa Dr Xiao Wang Dr Venetia Bigley Ian Dimmick Dr Trevor Booth et al.	Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation	2009
Dr Laura Jardine Professor Sophie Hambleton Dr Venetia Bigley Sarah Pagan Professor Matthew Collin et al.	Drug-Induced, NKG2D-Dependent Sensitization of ALL Cell Lines to NK Recognition	2009
Professor Matthew Collin Dr Venetia Bigley Professor Muzlifah Haniffa Dr Kevin Windebank	Langerin Plus Dermal Dendritic Cells: Closer to Langerhans Cell Histiocytosis than Langerhans Cells?	2009