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Chemically modified RNA: approaches and applications

Lookup NU author(s): Professor Olaf Heidenreich


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The modification of phosphate into phosphorothioate internucleotidic linkages in various RNAs and their usefulness in identifying phosphate positions essential for function are described. Several modifications of the 2'-hydroxyl group of the ribose, particularly the replacement by fluorine atoms and amino groups, is discussed. These studies have been concentrated on hammerhead ribozymes in order to determine hydroxyl groups important for the catalytic activity. In addition these derivatives have been instrumental in rendering ribozymes more stable toward nucleases.

Publication metadata

Author(s): Heidenreich O, Pieken W, Eckstein F

Publication type: Review

Publication status: Published

Journal: The FASEB Journal

Year: 1993

Volume: 7

Issue: 1

Pages: 90-96

ISSN (print): 0892-6638

ISSN (electronic): 1530-6860