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Acute Lymphoblastic Leukemia

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci

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Abstract

Precursor B-ALL (BCP-ALL) is associated with a good outcome in children. Cytogenetics is one of the gold standards for risk stratification for treatment that has contributed to improved survival. Although in T-ALL genetic analysis has not been used to guide therapy, it has contributed significantly to the understanding of the biology. State-of-the-art technologies in genomic and high throughput targeted sequencing are revealing novel genetic changes linked to biological and clinical features including outcome. A number of new biomarkers provide the potential for molecular targets for therapy with promise

Publication metadata

Author(s): Harrison CJ

Publication type: Article

Publication status: Published

Journal: Clinics in Laboratory Medicine

Year: 2011

Volume: 31

Issue: 4

Pages: 631-647

Print publication date: 06/10/2011

ISSN (print): 0272-2712

ISSN (electronic): 1557-9832

Publisher: W.B. Saunders Co.

URL: http://dx.doi.org/10.1016/j.cll.2011.08.016

DOI: 10.1016/j.cll.2011.08.016

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