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Lookup NU author(s): Professor Jane Endicott
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Genetic links between deregulation of the cell cycle and cancer are well established. There have been significant recent developments both in our understanding of the molecular mechanisms that control cell cycle progression and in methods for protein structure determination at atomic resolution. These advances have allowed the rational design of small molecules that modulate the cell cycle by competing for sites of protein - protein or protein - ATP interactions. There is considerable optimism that these compounds, a selection of which are here reviewed, will become clinically significant drugs. © 2005 Elsevier Ltd. All rights reserved.
Author(s): Welburn JPI, Endicott JA
Publication type: Review
Publication status: Published
Journal: Seminars in Cell & Developmental Biology
ISSN (print): 1084-9521
ISSN (electronic): 1096-3634
Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD