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Browsing publications by Professor Jane Endicott.

Newcastle AuthorsTitleYearFull text
Duncan Miller
Tristan Reuillon
Dr Lauren Molyneux
Dr Tim Blackburn
Dr Noel Edwards
et al.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor2022
Islam Al-Khawaldeh
Dr Christine Basmadjian
Dr Cinzia Bordoni
Dr Suzannah Harnor
Amy Heptinstall
et al.
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)2021
Dr Marco Salamina
Dr Richard Heath
Svitlana Korolchuk
Dr Arnaud Basle
Dr Martyna Pastok
et al.
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation2021
Dr Natalie Tatum
Professor Jane Endicott
Chatterboxes: the structural and functional diversity of cyclins2020
Daniel Wood
Svitlana Korolchuk
Dr Natalie Tatum
Lan Wang
Professor Jane Endicott
et al.
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition2019
Daniel Wood
Daniel Lopez Fernandez
Leanne Knight
Islam Al-Khawaldeh
Dr Conghao Gai
et al.
FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation2019
Stephanie Myers
Duncan Miller
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
et al.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
Duncan Miller
Dr Mathew Martin
Santosh Adhikari
Alfie Brennan
Professor Jane Endicott
et al.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach2018
Daniel Wood
Professor Jane Endicott
Structural insights into the functional diversity of the CDK–cyclin family2018
Christopher Coxon
Dr Suzannah Harnor
Dr Mathew Martin
Dr Benoit Carbain
Professor Bernard Golding
et al.
Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines2017
Stephen Hallett
Dr Martyna Pastok
Dr Anita Wittner
Professor Steve Wedge
Professor Martin Noble
et al.
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System2017
Dr Mathew Martin
Professor Jane Endicott
Professor Martin Noble
Structure-based discovery of cyclin-dependent protein kinase inhibitors2017
Svitlana Korolchuk
Dr Mathew Martin
Dr Will Stanley
Professor Martin Noble
Professor Jane Endicott
et al.
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK2015
Elisa Meschini
Dr Regina Mora Vidal
Dr Mathew Martin
Dr Will Stanley
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22015
Bailey Massa
Dr Mathew Martin
Professor Martin Noble
Professor Jane Endicott
Structural and functional characterization of Skp2-containing complexes2015
Dr Benoit Carbain
Dr Allyson Campbell
Dr Celine Cano
Professor Jane Endicott
Professor Bernard Golding
et al.
8-Substituted O-6-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode2014
Professor Jane Endicott
A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway2014
Dr Alison Hole
Professor Jane Endicott
Professor Martin Noble
An Inhibitor's-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States2014
Alex Liu
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones2014
Honorine Lebraud
Professor Bernard Golding
Elisa Meschini
Dr Celine Cano
Lan Wang
et al.
Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors2014
Andrew Shouksmith
Laura Evans
Professor Roger Griffin
Professor Bernard Golding
Professor Herbie Newell
et al.
Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex2014
Dr Mathew Martin
Elisa Meschini
Lan Wang
Dr Regina Mora Vidal
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22014
Dr Alison Hole
Dr Sonja Baumli
Professor Jane Endicott
Professor Martin Noble
Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity2013
Professor Jane Endicott
Professor Martin Noble
Structural characterization of the cyclin-dependent protein kinase family2013
Professor Martin Noble
Professor Jane Endicott
Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure-Activity Relationship, and Anticancer Activities2013
Professor Jane Endicott
Professor Martin Noble
The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant2013
Professor Martin Noble
Professor Jane Endicott
Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation2012
Professor Jane Endicott
Synthesis and in Vitro Evaluation of Selective CDK9 Inhibitors2012
Dr Sonja Baumli
Dr Alison Hole
Professor Martin Noble
Professor Jane Endicott
The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN5082012
Dr Sonja Baumli
Dr Alison Hole
Lan Wang
Professor Martin Noble
Professor Jane Endicott
et al.
The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b2012
Professor Jane Endicott
Professor Martin Noble
The Structural Basis for Control of Eukaryotic Protein Kinases2012
Professor Jane Endicott
The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in Vitro and in Vivo2012
Dr Ian Hardcastle
Alex Liu
Dr Eric Valeur
Anna Watson
Shafiq Ahmed
et al.
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency2011
Dr Karim Bennaceur
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones2011
Professor Martin Noble
Dr Ian Hardcastle
Professor Jane Endicott
Understanding small-molecule binding to MDM2: Insights into structural effects of isoindolinone inhibitors from NMR spectroscopy2011
Professor Martin Noble
Professor Jane Endicott
A new crystal form of Lys48-linked diubiquitin2010
Dr Alison Hole
Dr Sonja Baumli
Professor Jane Endicott
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells2010
Elisa Meschini
Professor Jane Endicott
Professor Bernard Golding
Dr Ian Hardcastle
Professor Herbie Newell
et al.
Design and synthesis of dual CDK2 and CDK7 inhibitors2010
Dr Sonja Baumli
Professor Jane Endicott
Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB2010
Professor Jane Endicott
Professor Martin Noble
Recent developments in cyclin-dependent kinase biochemical and structural studies2010
Professor Martin Noble
Professor Jane Endicott
Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn122010
Professor Jane Endicott
Professor Martin Noble
The structure of CDK4/cyclin D3 has implications for models of CDK activation2009
Professor Jane Endicott
Stuart Kemp
Dr Lucy Smyth
Dr Eric Valeur
Professor Bernard Golding
et al.
Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction2008
Professor Jane Endicott
CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases2008
Professor Jane Endicott
Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex2008
Professor Martin Noble
Professor Jane Endicott
Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design2008
Dr Julie Tucker
Professor Martin Noble
Professor Jane Endicott
How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A2007
Professor Jane Endicott
Meriolins, a new class of cell death-inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases2007
Professor Jane Endicott
Structural biology - Pass the protein2007
Dr Francesco Marchetti
Kerry Louise Sayle
Dr Johanne Bentley
Emeritus Professor Bill Clegg
Professor Nicola Curtin
et al.
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 22007
Dr Johanne Bentley
Professor Jane Endicott
Professor Martin Noble
Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity2006
Professor Roger Griffin
Andrew Henderson
Professor Nicola Curtin
Professor Jane Endicott
Dr Ian Hardcastle
et al.
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination2006
Professor Jane Endicott
Professor Martin Noble
Structure-based protein kinase inhibitor design2006
Professor Martin Noble
Professor Jane Endicott
Structures of the Dsk2 UBL and UBA domains and their complex2006
Professor Jane Endicott
Budding yeast Dsk2 protein forms a homodimer via its C-terminal UBA domain2005
Professor Martin Noble
Professor Jane Endicott
Exploiting structural principles to design cyclin-dependent kinase inhibitors2005
Professor Jane Endicott
Inhibition of the cell cycle with chemical inhibitors: A targeted approach2005
Professor Martin Noble
Professor Jane Endicott
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain2005
Professor Martin Noble
Professor Jane Endicott
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-32005
Professor Jane Endicott
Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes2005
Dr Ian Hardcastle
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
Professor Jane Endicott
et al.
N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 22004
Professor Martin Noble
Professor Jane Endicott
Protein kinase inhibitors: Insights into drug design from structure2004
Professor Jane Endicott
Professor Martin Noble
The role of structure in kinase-targeted inhibitor design2004
Dr Veronique Mesguiche
Rachel Parsons
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
et al.
4-Alkoxy-2,6-diaminopyrimidine derivatives: Inhibitors of cyclin dependent kinases 1 and 22003
Professor Martin Noble
Professor Jane Endicott
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects2003
Professor Jane Endicott
Professor Martin Noble
Molecular recognition of indigoids2003
Kerry Louise Sayle
Dr Johanne Bentley
Professor Alan Calvert
Dr YuZhu Cheng
Professor Nicola Curtin
et al.
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 22003
Professor Martin Noble
Professor Jane Endicott
Structures of P-falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition2003
Kerry Louise Sayle
Dr Veronique Mesguiche
Rachel Parsons
Professor Jane Endicott
Professor Martin Noble
et al.
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 22002
Professor Jane Endicott
Cyclin-dependent kinase homologues of Plasmodium falciparum2002
Dr Ashleigh Gibson
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
Professor Jane Endicott
et al.
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6-substituted guanine derivatives2002
Professor Jane Endicott
Professor Martin Noble
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 22002
Dr Johanne Bentley
Dr Christine Arris
Professor Nicola Curtin
Professor Jane Endicott
Dr Ashleigh Gibson
et al.
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor2002
Professor Jane Endicott
Professor Martin Noble
Structure-based design of cyclin-dependent kinase inhibitors2002
Professor Jane Endicott
Professor Martin Noble
Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells2001
Professor Jane Endicott
Professor Martin Noble
Inhibitor binding to active and inactive CDK2: The crystal structure of CDK2-cyclin A/indirubin-5-sulphonate2001
Professor Martin Noble
Professor Jane Endicott
Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex2000
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
Professor Bernard Golding
et al.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles2000
Dr Johanne Bentley
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
et al.
Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors2000
Professor Martin Noble
Professor Jane Endicott
Chemical inhibitors of cyclin-dependent kinases: Insights into design from X-ray crystallographic studies1999
Professor Jane Endicott
Professor Martin Noble
Dr Julie Tucker
Cyclin-dependent kinases: inhibition and substrate recognition1999
Professor Martin Noble
Professor Jane Endicott
Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity1999
Professor Jane Endicott
Professor Martin Noble
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases1999
Professor Martin Noble
Professor Jane Endicott
Signal transduction proteins: Structural basis of control by phosphorylation1999
Professor Martin Noble
Professor Jane Endicott
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases1999
Professor Jane Endicott
Professor Martin Noble
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Insights into CDK inhibitor design from X-ray crystallographic studies1998
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
O-6-alkylguanines as selective inhibitors of cyclin dependent kinases1998
Professor Jane Endicott
Professor Martin Noble
Structural principles in cell-cycle control: beyond the CDKs1998
Professor Martin Noble
Professor Jane Endicott
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK21997
Professor Martin Noble
Professor Jane Endicott
The cyclin box fold: protein recognition in cell-cycle and transcription control1997
Professor Jane Endicott
Professor Martin Noble
The structural basis for control by phosphorylation1997
Professor Jane Endicott
Professor Martin Noble
Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch1995
Professor Jane Endicott
The cell cycle and suc1: From structure to function?1995
Professor Martin Noble
Professor Jane Endicott
The crystal structure of Cyclin A1995
Professor Jane Endicott
Professor Martin Noble
The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein1995
Professor Jane Endicott
Mutational analysis supports a structural model for the cell cycle protein kinase p341994
Professor Jane Endicott
Characterization of the hemolysin transporter, HlyB, using an epitope insertion1992
Professor Jane Endicott
Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family1991
Professor Jane Endicott
The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance1989
Professor Jane Endicott
Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells1987
Professor Jane Endicott
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance1986