Publications by Professor Jane Endicott - ePrints

Browsing publications by Professor Jane Endicott.

Newcastle Authors	Title	Year
Rhianna Rowland Svitlana Korolchuk Dr Marco Salamina Dr Natalie Tatum Professor Martin Noble et al.	Cryo-EM structure of the CDK2-cyclin A-CDC25A complex	2024
Dr Celine Cano Professor Jane Endicott Dr Ian Hardcastle Dr Claire Jennings Suzanne Kyle et al.	Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile	2024
Dr Martyna Pastok Dr Shannon Turberville Dr Arnaud Basle Professor Martin Noble Professor Jane Endicott et al.	Structural requirements for the specific binding of CRABP2 to cyclin D3	2024
Rhianna Rowland Dr Richard Heath Professor Jane Endicott Professor Martin Noble Dr Marco Salamina et al.	Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1	2023
Dr Mathew Martin Professor Jane Endicott Professor Martin Noble Dr Natalie Tatum	Crystallographic fragment screening in academic cancer drug discovery	2023
Svitlana Korolchuk Professor Jane Endicott	Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation	2023
Dr Ian Hope Professor Jane Endicott Dr Jessica Watt	Emerging approaches to CDK inhibitor development, a structural perspective	2023
Gemma Davison Dr Mathew Martin Dr Shannon Turberville Selma Dormen Dr Richard Heath et al.	Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLites ─ Halogenated probes of druglike and peptide-like molecular interactions	2022
Duncan Miller Tristan Reuillon Dr Lauren Molyneux Dr Tim Blackburn Dr Noel Edwards et al.	Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor	2022
Islam Al-Khawaldeh Dr Christine Basmadjian Dr Cinzia Bordoni Dr Suzannah Harnor Amy Heptinstall et al.	An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)	2021
Dr Marco Salamina Dr Richard Heath Svitlana Korolchuk Dr Arnaud Basle Dr Martyna Pastok et al.	Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation	2021
Dr Natalie Tatum Professor Jane Endicott	Chatterboxes: the structural and functional diversity of cyclins	2020
Daniel Wood Svitlana Korolchuk Dr Natalie Tatum Lan Wang Professor Jane Endicott et al.	Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition	2019
Daniel Wood Daniel Lopez Fernandez Leanne Knight Islam Al-Khawaldeh Dr Conghao Gai et al.	FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation	2019
Stephanie Myers Duncan Miller Dr Lauren Molyneux Dr Mercedeh Arasta Dr Ruth Bawn et al.	Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4	2019
Duncan Miller Dr Mathew Martin Santosh Adhikari Alfie Brennan Professor Jane Endicott et al.	Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach	2018
Daniel Wood Professor Jane Endicott	Structural insights into the functional diversity of the CDK–cyclin family	2018
Christopher Coxon Dr Suzannah Harnor Dr Mathew Martin Dr Benoit Carbain Emeritus Professor Bernard Golding et al.	Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines	2017
Stephen Hallett Dr Martyna Pastok Dr Anita Wittner Professor Steve Wedge Professor Martin Noble et al.	Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System	2017
Dr Mathew Martin Professor Jane Endicott Professor Martin Noble	Structure-based discovery of cyclin-dependent protein kinase inhibitors	2017
Svitlana Korolchuk Dr Mathew Martin Dr Will Stanley Professor Martin Noble Professor Jane Endicott et al.	CDK1 structures reveal conserved and unique features of the essential cell cycle CDK	2015
Elisa Meschini Dr Regina Mora Vidal Dr Mathew Martin Dr Will Stanley Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2015
Bailey Massa Dr Mathew Martin Professor Martin Noble Professor Jane Endicott	Structural and functional characterization of Skp2-containing complexes	2015
Dr Benoit Carbain Dr Allyson Campbell Dr Celine Cano Professor Jane Endicott Emeritus Professor Bernard Golding et al.	8-Substituted O-6-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode	2014
Professor Jane Endicott	A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway	2014
Dr Alison Hole Professor Jane Endicott Professor Martin Noble	An Inhibitor's-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States	2014
Alex Liu Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones	2014
Honorine Lebraud Emeritus Professor Bernard Golding Elisa Meschini Dr Celine Cano Lan Wang et al.	Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors	2014
Andrew Shouksmith Laura Evans Professor Roger Griffin Emeritus Professor Bernard Golding Professor Herbie Newell et al.	Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex	2014
Dr Mathew Martin Elisa Meschini Lan Wang Dr Regina Mora Vidal Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2014
Dr Alison Hole Dr Sonja Baumli Professor Jane Endicott Professor Martin Noble	Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity	2013
Professor Jane Endicott Professor Martin Noble	Structural characterization of the cyclin-dependent protein kinase family	2013
Professor Martin Noble Professor Jane Endicott	Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure-Activity Relationship, and Anticancer Activities	2013
Professor Jane Endicott Professor Martin Noble	The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant	2013
Professor Martin Noble Professor Jane Endicott	Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation	2012
Professor Jane Endicott	Synthesis and in Vitro Evaluation of Selective CDK9 Inhibitors	2012
Dr Sonja Baumli Dr Alison Hole Professor Martin Noble Professor Jane Endicott	The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508	2012
Dr Sonja Baumli Dr Alison Hole Lan Wang Professor Martin Noble Professor Jane Endicott et al.	The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b	2012
Professor Jane Endicott Professor Martin Noble	The Structural Basis for Control of Eukaryotic Protein Kinases	2012
Professor Jane Endicott	The ubiquitin-associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is essential for the recognition of ubiquitin-proteasome system substrates both in Vitro and in Vivo	2012
Dr Ian Hardcastle Alex Liu Dr Eric Valeur Anna Watson Shafiq Ahmed et al.	Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency	2011
Dr Karim Bennaceur Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones	2011
Professor Martin Noble Dr Ian Hardcastle Professor Jane Endicott	Understanding small-molecule binding to MDM2: Insights into structural effects of isoindolinone inhibitors from NMR spectroscopy	2011
Professor Martin Noble Professor Jane Endicott	A new crystal form of Lys48-linked diubiquitin	2010
Dr Alison Hole Dr Sonja Baumli Professor Jane Endicott	CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells	2010
Elisa Meschini Professor Jane Endicott Emeritus Professor Bernard Golding Dr Ian Hardcastle Professor Herbie Newell et al.	Design and synthesis of dual CDK2 and CDK7 inhibitors	2010
Dr Sonja Baumli Professor Jane Endicott	Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB	2010
Professor Jane Endicott Professor Martin Noble	Recent developments in cyclin-dependent kinase biochemical and structural studies	2010
Professor Martin Noble Professor Jane Endicott	Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12	2010
Professor Jane Endicott Professor Martin Noble	The structure of CDK4/cyclin D3 has implications for models of CDK activation	2009
Professor Jane Endicott Stuart Kemp Dr Lucy Smyth Dr Eric Valeur Emeritus Professor Bernard Golding et al.	Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction	2008
Professor Jane Endicott	CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases	2008
Professor Jane Endicott	Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex	2008
Professor Martin Noble Professor Jane Endicott	Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design	2008
Dr Julie Tucker Professor Martin Noble Professor Jane Endicott	How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A	2007
Professor Jane Endicott	Meriolins, a new class of cell death-inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases	2007
Professor Jane Endicott	Structural biology - Pass the protein	2007
Dr Francesco Marchetti Kerry Louise Sayle Dr Johanne Bentley Professor William Clegg Professor Nicola Curtin et al.	Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 2	2007
Dr Johanne Bentley Professor Jane Endicott Professor Martin Noble	Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity	2006
Professor Roger Griffin Andrew Henderson Professor Nicola Curtin Professor Jane Endicott Dr Ian Hardcastle et al.	Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination	2006
Professor Jane Endicott Professor Martin Noble	Structure-based protein kinase inhibitor design	2006
Professor Martin Noble Professor Jane Endicott	Structures of the Dsk2 UBL and UBA domains and their complex	2006
Professor Jane Endicott	Budding yeast Dsk2 protein forms a homodimer via its C-terminal UBA domain	2005
Professor Martin Noble Professor Jane Endicott	Exploiting structural principles to design cyclin-dependent kinase inhibitors	2005
Professor Jane Endicott	Inhibition of the cell cycle with chemical inhibitors: A targeted approach	2005
Professor Martin Noble Professor Jane Endicott	Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain	2005
Professor Martin Noble Professor Jane Endicott	Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3	2005
Professor Jane Endicott	Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes	2005
Dr Ian Hardcastle Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin Professor Jane Endicott et al.	N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2	2004
Professor Martin Noble Professor Jane Endicott	Protein kinase inhibitors: Insights into drug design from structure	2004
Professor Jane Endicott Professor Martin Noble	The role of structure in kinase-targeted inhibitor design	2004
Dr Veronique Mesguiche Rachel Parsons Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin et al.	4-Alkoxy-2,6-diaminopyrimidine derivatives: Inhibitors of cyclin dependent kinases 1 and 2	2003
Professor Martin Noble Professor Jane Endicott	Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects	2003
Professor Jane Endicott Professor Martin Noble	Molecular recognition of indigoids	2003
Kerry Louise Sayle Dr Johanne Bentley Professor Alan Calvert Dr YuZhu Cheng Professor Nicola Curtin et al.	Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2	2003
Professor Martin Noble Professor Jane Endicott	Structures of P-falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition	2003
Kerry Louise Sayle Dr Veronique Mesguiche Rachel Parsons Professor Jane Endicott Professor Martin Noble et al.	4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2	2002
Professor Jane Endicott	Cyclin-dependent kinase homologues of Plasmodium falciparum	2002
Dr Ashleigh Gibson Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin Professor Jane Endicott et al.	Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6-substituted guanine derivatives	2002
Professor Jane Endicott Professor Martin Noble	Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2	2002
Dr Johanne Bentley Dr Christine Arris Professor Nicola Curtin Professor Jane Endicott Dr Ashleigh Gibson et al.	Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor	2002
Professor Jane Endicott Professor Martin Noble	Structure-based design of cyclin-dependent kinase inhibitors	2002
Professor Jane Endicott Professor Martin Noble	Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells	2001
Professor Jane Endicott Professor Martin Noble	Inhibitor binding to active and inactive CDK2: The crystal structure of CDK2-cyclin A/indirubin-5-sulphonate	2001
Professor Martin Noble Professor Jane Endicott	Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex	2000
Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott Emeritus Professor Bernard Golding et al.	Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles	2000
Dr Johanne Bentley Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott et al.	Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors	2000
Professor Martin Noble Professor Jane Endicott	Chemical inhibitors of cyclin-dependent kinases: Insights into design from X-ray crystallographic studies	1999
Professor Jane Endicott Professor Martin Noble Dr Julie Tucker	Cyclin-dependent kinases: inhibition and substrate recognition	1999
Professor Martin Noble Professor Jane Endicott	Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity	1999
Professor Jane Endicott Professor Martin Noble	Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases	1999
Professor Martin Noble Professor Jane Endicott	Signal transduction proteins: Structural basis of control by phosphorylation	1999
Professor Martin Noble Professor Jane Endicott	The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases	1999
Professor Jane Endicott Professor Martin Noble Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Insights into CDK inhibitor design from X-ray crystallographic studies	1998
Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	O-6-alkylguanines as selective inhibitors of cyclin dependent kinases	1998
Professor Jane Endicott Professor Martin Noble	Structural principles in cell-cycle control: beyond the CDKs	1998
Professor Martin Noble Professor Jane Endicott	Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2	1997
Professor Martin Noble Professor Jane Endicott	The cyclin box fold: protein recognition in cell-cycle and transcription control	1997
Professor Jane Endicott Professor Martin Noble	The structural basis for control by phosphorylation	1997
Professor Jane Endicott Professor Martin Noble	Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch	1995
Professor Jane Endicott	The cell cycle and suc1: From structure to function?	1995
Professor Martin Noble Professor Jane Endicott	The crystal structure of Cyclin A	1995
Professor Jane Endicott Professor Martin Noble	The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein	1995
Professor Jane Endicott	Mutational analysis supports a structural model for the cell cycle protein kinase p34	1994
Professor Jane Endicott	Characterization of the hemolysin transporter, HlyB, using an epitope insertion	1992
Professor Jane Endicott	Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family	1991
Professor Jane Endicott	The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance	1989
Professor Jane Endicott	Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells	1987
Professor Jane Endicott	Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance	1986