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Lookup NU author(s): Dr Laura Greaves,
Dr Martin Barron,
Emeritus Professor Thomas Kirkwood,
Emeritus Professor Doug Turnbull
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Mitochondrial DNA mutations and associated defects in cytochrome c oxidase (COX) are proposed to play an important role in human ageing; however there have been limited studies on the frequency of these defects in normal mouse ageing. Here we compare COX-deficiency in two epithelial tissues; the colon and the ciliary epithelium, from human and mouse. The pattern of accumulation of COX-deficiency is similar in both tissues in the two species; however the frequency of colonic crypts with COX-deficiency in aged humans is significantly higher than in aged mice, whereas the levels of COX-deficiency in the ciliary epithelium are higher in the mouse than in humans. This suggests the impact of mitochondrial defects on normal ageing may differ significantly between species. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Author(s): Greaves LC, Barron MJ, Campbell-Shiel G, Kirkwood TBL, Turnbull DM
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
Print publication date: 12/10/2011
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier Ireland Ltd
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