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Differences in the accumulation of mitochondrial defects with age in mice and humans

Lookup NU author(s): Professor Laura GreavesORCiD, Dr Martin Barron, Emeritus Professor Thomas Kirkwood, Emeritus Professor Doug Turnbull

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Abstract

Mitochondrial DNA mutations and associated defects in cytochrome c oxidase (COX) are proposed to play an important role in human ageing; however there have been limited studies on the frequency of these defects in normal mouse ageing. Here we compare COX-deficiency in two epithelial tissues; the colon and the ciliary epithelium, from human and mouse. The pattern of accumulation of COX-deficiency is similar in both tissues in the two species; however the frequency of colonic crypts with COX-deficiency in aged humans is significantly higher than in aged mice, whereas the levels of COX-deficiency in the ciliary epithelium are higher in the mouse than in humans. This suggests the impact of mitochondrial defects on normal ageing may differ significantly between species. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Greaves LC, Barron MJ, Campbell-Shiel G, Kirkwood TBL, Turnbull DM

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2011

Volume: 132

Issue: 11-12

Pages: 588-591

Print publication date: 12/10/2011

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.mad.2011.10.004

DOI: 10.1016/j.mad.2011.10.004

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