George Kelly Dr Tetsushi Kataura Dr Johan Panek Hanna Salmonowicz Hannah Kendall et al. | Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule | 2024 |
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Hanna Salmonowicz Dr James Chapman George Kelly Professor Laura Greaves Professor Derek Mann et al. | Apoptotic stress causes mtDNA release during senescence and drives the SASP | 2023 |
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Dr Julia Whitehall Dr Anna Smith Professor Laura Greaves
| Mitochondrial DNA Mutations and Ageing | 2023 |
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Dr Ashwin Sachdeva Dr Christopher Carey Dr Amy Vincent Professor Laura Greaves Professor Rakesh Heer et al. | Automated quantitative high‑throughput multiplex immunofuorescence pipeline to evaluate OXPHOS defects in formalin‑fxed human prostate tissue | 2022 |
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Xuefei Yu Dr Catherine Arden Dr Rolando Berlinguer Palmini Dr Chun Chen Carla Bradshaw et al. | Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation | 2022 |
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Dr Anna Smith Dr Julia Whitehall Professor Laura Greaves
| Mitochondrial DNA mutations in ageing and cancer | 2022 |
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Dr Craig Stamp Dr Julia Whitehall Dr Anna Smith Dr David Houghton Carla Bradshaw et al. | Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon | 2021 |
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Amy Fuller Dr Nduka Okwose Jadine Scragg Professor Christopher Eggett Peter Luke et al. | The effect of age on mechanisms of exercise tolerance: Reduced arteriovenous oxygen difference causes lower oxygen consumption in older people | 2021 |
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Dr Julia Whitehall Professor Laura Greaves
| Aberrant mitochondrial function in ageing and cancer | 2020 |
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Dr Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al. | Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis | 2020 |
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Dr Philip Dobson Dr Ella Dennis Dan Hipps Dr Amy Reeve Dr Alex Laude et al. | Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss | 2020 |
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Dr Conor Lawless Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull Dr Amy Vincent et al. | The rise and rise of mitochondrial DNA mutations | 2020 |
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Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al. | A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices | 2019 |
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Dr Fiona Malcomson Dr Stella Breininger Khalil ElGendy Aj Joel Thilanka Ranathunga et al. | Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up | 2019 |
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Dr Stella Breininger Dr Fiona Malcomson Dr Sonny Afshar Emeritus Professor Doug Turnbull Professor Laura Greaves et al. | Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk | 2019 |
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Rhys Anderson Anthony Lagnado Damien Maggiorani Dr Anna Walaszczyk Emily Dookun et al. | Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence | 2019 |
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Professor Laura Greaves Professor Robert Taylor Dr Jim Stewart
| A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency | 2018 |
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Dr Dave Houghton Professor Christopher Stewart Dr Craig Stamp Professor Anil Wipat Professor Mike Trenell et al. | Age-related mitochondrial dysfunction influences the mouse intestinal microbiome composition | 2018 |
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Tianhong Su Dr John Grady Sorena Afshar Professor Robert Taylor Emeritus Professor Doug Turnbull et al. | Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations | 2018 |
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Dr Craig Stamp Dr Anze Zupanic Ashwin Sachdeva Dr Elizabeth Stoll Dr Daryl Shanley et al. | Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts | 2018 |
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Tianhong Su Emeritus Professor Doug Turnbull Professor Laura Greaves
| Roles of mitochondrial DNA mutations in stem cell ageing | 2018 |
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Dr Dave Houghton Professor Christopher Stewart Dr Craig Stamp Professor Anil Wipat Professor Mike Trenell et al. | Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition | 2017 |
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Alex Bury Dr Angela Pyle Dr Joanna Elson Professor Laura Greaves Dr Christopher Morris et al. | Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease | 2017 |
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Dr Mohammad Moad Laura Wilson Rob Pickard Emeritus Professor Doug Turnbull Professor Robert Taylor et al. | Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates | 2017 |
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Holly Baines Dr Craig Stamp Professor Laura Greaves Dr Jim Stewart
| A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease | 2016 |
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Ashwin Sachdeva Dr Amira El-Sherif Emeritus Professor Doug Turnbull Professor Laura Greaves Professor Rakesh Heer et al. | Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis | 2016 |
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Dr Ellen Tullo Professor Laura Greaves Dr Luisa Wakeling
| Involving older people in the design, development, and delivery of an innovative module on aging for undergraduate students | 2016 |
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Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al. | Mitochondria are required for pro-ageing features of the senescent phenotype | 2016 |
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Dr Philip Dobson Dr Mariana Rocha Dr John Grady Alexia Chrysostomou Sharon Watson et al. | Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA -/- mice | 2016 |
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Professor Grainne Gorman Dr Hue Hornig - Do Dr Helen Tuppen Professor Laura Greaves Dr Langping He et al. | Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression | 2015 |
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Professor Laura Greaves Dr Anne Grunewald
| SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts | 2015 |
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Dr Joanna Elson Dr Paul Smith Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al. | The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease | 2015 |
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Professor Laura Greaves Professor Robert Taylor
| Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy | 2014 |
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Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al. | Chronic inflammation induces telomere dysfunction and accelerates ageing in mice | 2014 |
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Professor Laura Greaves Marco Nooteboom Dr Joanna Elson Dr Helen Tuppen Geoffrey Taylor et al. | Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing | 2014 |
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Dr Stuart Williamson Laura Wilson Graeme Williamson Professor Laura Greaves Dr Helen Tuppen et al. | Finding a niche. The location of human prostate stem cells | 2014 |
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Holly Baines Emeritus Professor Doug Turnbull Professor Laura Greaves
| Human stem cell aging: do mitochondrial DNA mutations have a causal role? | 2014 |
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Holly Baines Dr Jim Stewart Craig Stamp Dr Anze Zupanic Emeritus Professor Thomas Kirkwood et al. | Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans | 2014 |
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Dr Paul Smith Dr Joanna Elson Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al. | The role of the mitochondrial ribosome in human disease: Searching for mutations in 12S mitochondrial rRNA with high disruptive potential | 2013 |
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Professor Laura Greaves Dr Joanna Elson Dr John Grady Geoffrey Taylor Professor Robert Taylor et al. | Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations | 2012 |
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Dr John Blackwood Professor Laura Greaves Laura Wilson Rob Pickard Professor Majlinda Lako et al. | Lineage tracking in situ: Where are the prostate stem cells? What are they doing? | 2012 |
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Professor Laura Greaves Dr Amy Reeve Professor Robert Taylor Emeritus Professor Doug Turnbull
| Mitochondrial DNA and disease | 2012 |
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Dr John Blackwood Dr Stuart Williamson Professor Laura Greaves Laura Wilson Dr Anastasia Hepburn et al. | In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells | 2011 |
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Professor Laura Greaves Dr Martin Barron Emeritus Professor Thomas Kirkwood Emeritus Professor Doug Turnbull
| Differences in the accumulation of mitochondrial defects with age in mice and humans | 2011 |
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Marco Nooteboom Professor Robert Taylor Professor Robert Lightowlers Emeritus Professor Thomas Kirkwood Professor John Mathers et al. | Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts | 2010 |
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Professor Laura Greaves Dr Martin Barron Dr Stefan Plusa Emeritus Professor Thomas Kirkwood Professor John Mathers et al. | Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts | 2010 |
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Professor Laura Greaves Dr Martin Barron Dr Stefan Plusa Emeritus Professor Thomas Kirkwood Professor John Mathers et al. | Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts | 2010 |
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Professor Laura Greaves Dr Patrick Yu Wai Man Kim Krishnan Nina Beadle Dr Martin Barron et al. | Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO | 2010 |
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Dr Patrick Yu Wai Man Dr Gillian Borthwick Dr Langping He Geoffrey Taylor Professor Laura Greaves et al. | Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles | 2010 |
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Dr Nimantha De Alwis Emeritus Professor Doug Turnbull Professor Robert Taylor Professor Laura Greaves Professor Patrick Chinnery et al. | A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues | 2009 |
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Dr Don Mahad Dr Iryna Ziabreva Graham Campbell Dr Julie Murphy Dr Amy Reeve et al. | Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells | 2009 |
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Emeritus Professor Doug Turnbull Professor Robert Taylor Professor Laura Greaves Professor Patrick Chinnery
| Locating the Stem Cell Niche and Tracing Hepatocyte Lineages in Human Liver | 2009 |
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Professor Laura Greaves Emeritus Professor Doug Turnbull
| Mitochondrial DNA mutations and ageing | 2009 |
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Professor Laura Greaves Professor John Mathers Professor Robert Taylor Emeritus Professor Doug Turnbull
| Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer? | 2009 |
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Professor Laura Greaves Nina Beadle Geoffrey Taylor Dr Daniel Commane Professor John Mathers et al. | Quantification of mitochondrial DNA mutation load | 2009 |
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Professor Robert Taylor Professor Laura Greaves Dr Martin Barron Philip Griffiths Emeritus Professor Doug Turnbull et al. | A histochemical and molecular genetic investigation of the selective, extraocular muscle involvement in chronic progressive external ophthalmoplegia | 2008 |
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Professor Laura Greaves Professor Robert Taylor Emeritus Professor Doug Turnbull
| Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells | 2008 |
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Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull
| Mitochondrial DNA mutations and aging | 2007 |
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Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull
| Mitochondrial DNA mutations and aging | 2007 |
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Professor Laura Greaves Dr Daniel Commane Dr Hazel Greetham Professor Robert Taylor Emeritus Professor Doug Turnbull et al. | Novel preliminary findings of mitochondrial DNA mutations in colonic crypts of patients with diverticular disease (the Boricc study) | 2007 |
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Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull
| The ageing mitochondrial genome | 2007 |
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Professor Laura Greaves Emeritus Professor Doug Turnbull
| Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way | 2006 |
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Dr Simon Wilkinson Professor Laura Greaves Professor Faith Williams
| Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies | 2006 |
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Dr Ramesh Arasaradnam Professor Laura Greaves Dr Daniel Commane Professor John Mathers Professor Robert Taylor et al. | Mitochondrial DNA (MTDNA) mutations in human colonic crypts: A novel biomarker of colorectal cancer. | 2006 |
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Professor Laura Greaves Professor Robert Taylor Dr Martin Barron Emeritus Professor Doug Turnbull
| Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission | 2006 |
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Professor Laura Greaves Professor Robert Taylor
| Mitochondrial DNA mutations in human disease | 2006 |
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Professor Laura Greaves Emeritus Professor Doug Turnbull
| Modelling of the expansion of normal human colonic crypts | 2006 |
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Professor Laura Greaves Emeritus Professor Doug Turnbull
| Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis | 2005 |
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Professor Laura Greaves Emeritus Professor Doug Turnbull
| Clusters of phenotypically-related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis | 2005 |
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Professor Robert Taylor Dr Langping He Professor Laura Greaves Geoffrey Taylor Dr Martin Barron et al. | Mitochondrial DNA mutations in human colonic crypt stem cells | 2004 |
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Professor Laura Greaves Dr Martin Barron Professor Robert Taylor Emeritus Professor Doug Turnbull
| Mitochondrial DNA mutations in human colonic crypt stem cells - implications for function | 2004 |
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Professor Robert Taylor Dr Martin Barron Dr Gillian Borthwick Professor Patrick Chinnery Dr David Samuels et al. | Mitochondrial DNA mutations and aging in human colonic crypts and stem cells | 2003 |
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Professor Robert Taylor Dr Martin Barron Dr Gillian Borthwick Professor Patrick Chinnery Dr David Samuels et al. | Mitochondrial DNA mutations in human colonic crypt stem cells | 2003 |
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Professor Laura Greaves Dr Simon Wilkinson Professor Faith Williams
| Factors affecting percutaneous absorption of caffeine in vitro | 2002 |
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