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Accuracy of the revised 2010 TNM classification in predicting the prognosis of patients treated for renal cell cancer in the north east of England

Lookup NU author(s): Dr Amira El-Sherif, Dr Mark Johnson, Professor Naeem Soomro, Dr Rakesh Heer

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Abstract

Background The TNM classification for renal cell cancer (RCC) should accurately predict and assign prognostic information for patients. In this study the recent 2010 revision to the TNM classification was compared with the previous 2002 classification with regard to survival outcomes. Methods All patients having radical nephrectomy for RCC in the 5-year period 2004-8 at a tertiary referral centre were included. Pathological and radiological records were reviewed to identify TNM stage (2002 and 2010 classification) and survival data were captured. Results 345 patients with RCC were identified. Based on the 2002 TNM staging system and using outcomes in T1 staged tumours as a baseline, statistically significant differences in disease-specific survival were noted between patients with T1 and T3b tumours (log rank p<0.001) but not between those with T1 and T3a tumours (p=0.33). However, when tumour stage was reassigned according to the 2010 classification, patients with T3a tumours were also found to do statistically worse than T1 staged disease (p<0.001). Conclusion In our cohort, the new 2010 TNM reclassification of T3 tumours showed better correlation with predicting worsening outcomes compared with localised disease.


Publication metadata

Author(s): Veeratterapillay R, Simren R, El-Sherif A, Johnson MI, Soomro N, Heer R

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 2012

Volume: 65

Issue: 4

Pages: 367-371

Print publication date: 28/01/2012

ISSN (print): 0021-9746

ISSN (electronic):

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/jclinpath-2011-200468

DOI: 10.1136/jclinpath-2011-200468


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