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Browsing publications by Professor Rakesh Heer.

Newcastle AuthorsTitleYearFull text
Dr Adriana Buskin
Parmveer Singh
Professor Craig Robson
Professor Rakesh Heer
A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease2022
Dr Ashwin Sachdeva
Dr Christopher Carey
Dr Amy Vincent
Dr Laura Greaves
Professor Rakesh Heer
et al.
Automated quantitative high‑throughput multiplex immunofuorescence pipeline to evaluate OXPHOS defects in formalin‑fxed human prostate tissue2022
Dr Michael Grayling
Professor Rakesh Heer
Professor James Wason
Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials2022
Professor Rakesh Heer
Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium2022
Laura Wilson
Professor Rakesh Heer
Development, maturation, and maintenance of human prostate inferred from somatic mutations2021
Professor Rakesh Heer
Major Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes2021
Dr Cole Sims
Dr Adriana Buskin
Professor Rakesh Heer
Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines2021
Dr Daniel Leongamornlert
Professor Rakesh Heer
The mutational landscape of human somatic and germline cells2021
Bhavan Rai
Professor Luke Vale
Professor Rakesh Heer
Time to Turn on the Blue Lights: A Systematic Review and Meta-analysis of Photodynamic Diagnosis for Bladder Cancer2021
Anna Smith
Dr Julia Whitehall
Carla Bradshaw
Dr Fiona Robertson
Dr Alasdair Blain
et al.
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis2020
Dr Anastasia Hepburn
Dr Cole Sims
Dr Adriana Buskin
Professor Rakesh Heer
Engineering Prostate Cancer from Induced Pluripotent Stem Cells-New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies2020
Dr Anastasia Hepburn
Emma Curry
Dr Mohammad Moad
Laura Wilson
Parmveer Singh
et al.
Propagation of human prostate tissue from induced pluripotent stem cells2020
Dr Anastasia Hepburn
Laura Wilson
Evangelia Kounatidou
Amy Barnard
Philip Berry
et al.
Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance (Oncogene, (2019), 10.1038/s41388-019-0712-y)2019
Dr Emma Clark
Dr Miranda Morton
Shriya Sharma
Dr Holly Fisher
Denise Howel
et al.
Prostate cancer androgen receptor splice variant 7 biomarker study - A multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol2019
Dr Anastasia Hepburn
Laura Wilson
Evangelia Kounatidou
Amy Barnard
Philip Berry
et al.
The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance2019
Dr Urszula McClurg
Svitlana Korolchuk
Dr Stuart McCracken
Professor Rakesh Heer
Laura Wilson
et al.
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein2018
Professor Rakesh Heer
Laparoscopic renal surgery is here to stay2018
Dr Craig Stamp
Dr Anze Zupanic
Ashwin Sachdeva
Dr Elizabeth Stoll
Dr Daryl Shanley
et al.
Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts2018
Dr Anastasia Hepburn
Professor Rakesh Heer
Urothelial carcinoma stem cells: Current concepts, controversies, and methods2018
Dr Mohammad Moad
Professor Rakesh Heer
A Unifying Theory of Branching Morphogenesis2017
Dr Mohammad Moad
Laura Wilson
Rob Pickard
Emeritus Professor Doug Turnbull
Professor Robert Taylor
et al.
Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates2017
Dr Mohammad Moad
Gladys -
Professor Craig Robson
Professor Rakesh Heer
Role of Induced Pluripotent Stem Cells in Urological Disease Modeling and Repair2017
Ashwin Sachdeva
Dr Amira El-Sherif
Emeritus Professor Doug Turnbull
Dr Laura Greaves
Professor Rakesh Heer
et al.
Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis2016
Dr Rachel Pearson
Professor Peter Thelwall
Jim Snell
Dr Piotr Pieniazek
Professor Rakesh Heer
et al.
Evaluation of early response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using dynamic contrast-enhanced MRI and diffusion weighted MRI: MARBLE study2016
Dr Rachel Pearson
Professor Peter Thelwall
Jim Snell
Dr Piotr Pieniazek
Professor Rakesh Heer
et al.
Evaluation of early responses to neoadjuvant chemotherapy in muscle-invasive bladder cancer using a dynamic contrast-enhanced MRI and diffusion-weighted MRI: MARBLE study2016
Nicola Lazzarini
Dr Pawel Widera
Dr Stuart Williamson
Professor Rakesh Heer
Professor Natalio Krasnogor
et al.
Functional networks inference from machine learning models2016
Professor Rakesh Heer
Dr Mark Johnson
High-Risk Non-Muscle-Invasive Bladder Cancer—Therapy Options During Intravesical BCG Shortage2016
Professor Naeem Soomro
Professor Rakesh Heer
Contrast-enhanced CT in 100 clear cell renal cell cancers - an analysis of enhancement, tumour size, and survival2015
Professor Rakesh Heer
Delays in the diagnosis and treatment of muscle invasive bladder cancer: A pilot project mapping the pathway2015
Professor Rakesh Heer
Long-term oncological outcomes of patients undergoing neoadjuvant chemotherapy and cystectomy for muscle invasive bladder cancer2015
Ahmed Abroaf
Dr Luke Gaughan
Professor Craig Robson
Professor Rakesh Heer
The co-chaperone p23 promotes prostate cancer motility and metastasis2015
Emma Curry
Dr Mohammad Moad
Professor Craig Robson
Professor Rakesh Heer
Using induced pluripotent stem cells as a tool for modelling carcinogenesis2015
Professor Rakesh Heer
Can we deliver randomized trials of focal therapy in prostate cancer?2014
Dr Stuart Williamson
Laura Wilson
Graeme Williamson
Dr Laura Greaves
Dr Helen Tuppen
et al.
Finding a niche. The location of human prostate stem cells2014
Professor Nicola Curtin
Professor Rakesh Heer
Investigating PARP-1 expression and activity in male and female, benign and malignant renal tissue2014
Alistair Rogers
Professor Rakesh Heer
Metastases at presentation of transitional cell muscle invasive bladder carcinoma in a 10 year series of 427 patients: is staging computed tomography of the thorax always required?2014
Dr Mohammad Moad
Dr Deepali Pal
Dr Anastasia Hepburn
Dr Stuart Williamson
Laura Wilson
et al.
A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming human prostate and bladder cells into induced pluripotent stem cells2013
Dr Stuart Williamson
Dr Alice Hartley
Professor Rakesh Heer
A review of tasquinimod in the treatment of advanced prostate cancer2013
Dr Stuart Williamson
Dr Anastasia Hepburn
Laura Wilson
Professor Hing Leung
Professor Craig Robson
et al.
Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer2013
Dr Mohammad Moad
Dr Anastasia Hepburn
Professor Majlinda Lako
Dr Deepali Pal
Professor Rakesh Heer
et al.
Generation of induced pluripotent stem cells from human urinary tract cells2013
Dr Anastasia Hepburn
Dr Luke Gaughan
Dr Stuart Williamson
Dr Deepali Pal
Dr Mohammad Moad
et al.
Investigating the regulation and effects on androgen receptor expression using a novel stem cell environment model of castration resistant prostate cancer2013
Dr Stuart McCracken
Professor Rakesh Heer
Penile strangulation by a substantial metal napkin ring: successful removal with medtronic midas rex® legend® stylus® drill system2013
Dr Claire Townes
Ased Ali
Dr Deepali Pal
Dr Stuart Williamson
Professor Rakesh Heer
et al.
Prostate specific antigen enhances the innate defence of prostatic epithelium against Escherichia coli infection2013
Professor Rakesh Heer
Dr Anastasia Hepburn
Dr Stuart Williamson
Dr Amy Kennedy
Dr Amira El-Sherif
et al.
Renal differentiation from adult spermatogonial stem cells2013
Dr Deepali Pal
Dr Mohammad Moad
Dr Anastasia Hepburn
Dr Stuart Williamson
Professor Craig Robson
et al.
Reply from Authors re: "Reprogramming Stromal Cell from the Urinary Tract and Prostate: A Trip to Pluripotency and Back?"2013
Dr Deepali Pal
Dr Mohammad Moad
Dr Anastasia Hepburn
Dr Stuart Williamson
Professor Craig Robson
et al.
Reply from Authors re: Felix Wezel, Jennifer Southgate. Reprogramming Stromal Cells from the Urinary Tract and Prostate: A Trip to Pluripotency and Back? Eur Urol 2013;64:762-42013
Dr Anastasia Hepburn
Laura Wilson
Professor Craig Robson
Professor Rakesh Heer
Stockpiling testosterone; A unique mechanism of progression to castrate resistant disease2013
Dr Kelly Coffey
Lynsey Rogerson
Claudia Ryan-Munden
Dhuha Alkharaif
Dr Jacqueline Stockley
et al.
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover2013
Dr Deepali Pal
Anastasia Rigas
Dr Stuart Williamson
Dr Mohammad Moad
Dr Jane Carr-Wilkinson
et al.
Induced pluripotent stem cell (iPSC) re-programming in the human prostate2012
Professor Rakesh Heer
Dr Deepali Pal
David Rix
Dr Mark Johnson
Secondary haemorrhage following transurethral resection of bladder tumour — is it always related to infection?2012
Dr Deepali Pal
Anastasia Rigas
Dr Stuart Williamson
Dr Mohammad Moad
Professor Craig Robson
et al.
The role of epithelial to mesenchymal transition (EMT) in iPS induction of human prostate2012
Dr Amira El-Sherif
Dr Mark Johnson
Professor Naeem Soomro
Professor Rakesh Heer
Accuracy of the revised 2010 TNM classification in predicting the prognosis of patients treated for renal cell cancer in the north east of England2012
Dr Amira El-Sherif
Dr Mark Johnson
Professor Naeem Soomro
Professor Rakesh Heer
Can the Kattan nomogram still accurately predict prognosis in renal cell carcinoma using the revised 2010 tumor-nodes-metastasis reclassification?2012
Dr Stuart Williamson
Dr Anastasia Hepburn
Laura Wilson
Dr Kelly Coffey
Claudia Ryan-Munden
et al.
Human α2β1HI CD133+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor2012
Dr John Blackwood
Dr Laura Greaves
Laura Wilson
Rob Pickard
Professor Majlinda Lako
et al.
Lineage tracking in situ: Where are the prostate stem cells? What are they doing?2012
Anastasia Rigas
Dr Stuart Williamson
Dr Amy Kennedy
Dr Amira El-Sherif
Professor Naeem Soomro
et al.
Renal differentiation from adult spermatogonial stem cells2012
Dr Anastasia Hepburn
Dr Stuart Williamson
Dr Amira El-Sherif
Dr Neha Sahay
Huw Thomas
et al.
Side Population in Human Non-Muscle Invasive Bladder Cancer Enriches for Cancer Stem Cells That Are Maintained by MAPK Signalling2012
Dr John Blackwood
Dr Stuart Williamson
Dr Laura Greaves
Laura Wilson
Dr Anastasia Hepburn
et al.
In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells2011
Dr Stuart Williamson
Dr Anastasia Hepburn
Professor Craig Robson
Professor Rakesh Heer
An update on the prostate cancer stem cell model-CD133+ve stem cell enriched human prostate cells express active androgen receptor2011
Dr Matthew Jackson
Professor Rakesh Heer
Dr Amira El-Sherif
Dr Petros Perros
Carcinoid tumour in an ileocystoplasty: A reminder to consider native bowel disease in the reconstructed urinary tract2011
Dr Deepali Pal
Dr Stuart Williamson
Professor Craig Robson
Dr Anastasia Hepburn
Professor Rakesh Heer
et al.
Characterising potential for pluripotency induction in human prostate tissue2011
Dr Stuart Williamson
Dr Anastasia Hepburn
Professor Craig Robson
Professor Rakesh Heer
Comparative meta-analysis of the human prostate stem cell transcriptome demonstrates that progenitor cells are the site of malignant transformation2011
Dr Anastasia Hepburn
Dr Stuart Williamson
Professor Craig Robson
Professor Rakesh Heer
Side population in human bladder cancer enriches for cancer stem cells that can be targeted by MAPK inhibition2011
Dr Deepali Pal
Professor Craig Robson
Dr Stuart Williamson
Professor Karim Nayernia
Dr Hamid Reza Soleimanpour Lichaei
et al.
Stem-cell regulatory protein Piwil2 enriches for known stem-cell and cancer stem-cell markers in prostate cancer cells2011
Dr Simon Pridgeon
Professor Rakesh Heer
Gordon Taylor
Professor Herbie Newell
Kieran O'Toole
et al.
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer2011
Professor Rakesh Heer
Dr Anastasia Hepburn
Dr Tim Cheek
Rob Pickard
Professor Hing Leung
et al.
Phenotypic Modulation of Human Urinary Tract Stroma-derived Fibroblasts by Transforming Growth Factor β32010
Dr Stuart McCracken
Professor Rakesh Heer
Dr Marie Mathers
Benjamin Jenkins
Professor Craig Robson
et al.
Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer2008
Professor Rakesh Heer
Professor Craig Robson
Editorial comment on: Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate2008
Dr Emma Clark
Dr Anne Coulson
Caroline Dalgliesh
Dr Prabhakar Rajan
Professor Rakesh Heer
et al.
The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer2008
Professor Rakesh Heer
Professor Craig Robson
Dr Brian Shenton
Professor Hing Leung
The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population (vol 2, pg 572, 2007)2008
Dr Nicholas Clarke
Professor Rakesh Heer
Dr Tim Cheek
Rob Pickard
Changing the phenotype of urethral stroma by treatment with transforming growth factor beta-32007
Professor Rakesh Heer
Professor Craig Robson
Dr Brian Shenton
Professor Hing Leung
The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population2007
Professor Rakesh Heer
Dr Anne Collins
Professor Craig Robson
Dr Brian Shenton
Professor Hing Leung
et al.
KGF suppresses α2β1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium2006
Dr Arthur Mckie
David Douglas
Dr Sharon Olijslagers
Julia Patch
Mahmoud Omar
et al.
Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer2005
Dr Stuart McCracken
Benjamin Jenkins
Professor Rakesh Heer
Dr Marie Mathers
Professor Craig Robson
et al.
Expression analysis of the MEK5/ERK5 signalling pathway in human prostate cancer2005
Professor Rakesh Heer
Dr Trevor Dorkin
Thomas Griffiths
Laurence Rangecroft
A prospective audit of hypospadias correction in a regional paediatric surgery centre2004
Professor Rakesh Heer
David Douglas
Professor Craig Robson
Professor Hing Leung
Fibroblast growth factor (FGF) 17 expression is up-regulated human prostate cancer and correlates to clinical prognosis2004
Professor Rakesh Heer
David Douglas
Dr Marie Mathers
Professor Craig Robson
Professor Hing Leung
et al.
Fibroblast growth factor 17 is over-expressed in human prostate cancer2004
Professor Rakesh Heer
Dr Anne Collins
Professor Craig Robson
Professor Hing Leung
Role of keratinocyte growth factor (KGF) and androgen in human prostatic epithelial stem cell differentiation2004
Professor Rakesh Heer
Dr Jyotsna Shrimankar
Clive Griffith
Untitled - Letter2004
Professor Rakesh Heer
Dr Jyotsna Shrimankar
Clive Griffith
Granulomatous mastitis can mimic breast cancer on clinical, radiological or cytological examination: a cautionary tale2003
Professor Rakesh Heer
The effects of sublingual glyceryl trinitrate on walking distance in patients with intermittent claudication. A randomised, doubled-blind, placebo-controlled, cross-over study2001
Professor Rakesh Heer
Dr Stefan Plusa
How to alter surgical practice? The use of guidelines to encourage day-case haemorrhoidectomy2000
Professor Rakesh Heer
Vascular surgical society of great britain and ireland: prospective randomized double-blind placebo-controlled crossover study to assess the effect of sublingual glyceryl trinitrate in patients with intermittent claudication1999