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Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

Lookup NU author(s): Professor Miles Whittington


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The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range gamma-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.

Publication metadata

Author(s): Melzer S, Michael M, Caputi A, Eliava M, Fuchs EC, Whittington MA, Monyer H

Publication type: Article

Publication status: Published

Journal: Science

Year: 2012

Volume: 335

Issue: 6075

Pages: 1506-1510

Print publication date: 23/03/2012

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science


DOI: 10.1126/science.1217139


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Funder referenceFunder name
01GQ1003AGerman Ministry of Education and Research (BMBF)
250047European Research Council