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Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial

Lookup NU author(s): Professor Anthony Moorman

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Abstract

Although the incidence rate of acute lymphoblastic leukaemia (ALL) is slightly higher in older than in younger adults, response rates to induction chemotherapy and survival rates are poorer. The contribution of disease-related versus treatment-related factors remains unclear. We analysed 100 older patients (aged 55-65 years) treated on the UKALLXII/ECOG2993 trial compared with 1814 younger patients (aged 14-54 years). Baseline characteristics, induction chemotherapy course, infections, drug reductions and survival outcomes were compared. There were more Philadelphia-positive (Ph+) patients in the older group (28% vs. 17%, P = 0.02), and a trend towards higher combined cytogenetic risk score (46% vs. 35%, P = 0.07). The complete remission rate in older patients was worse (73% vs. 93%, P < 0.0001) as was 5-year overall survival (21% vs. 41%, P < 0.0001) and event-free survival (EFS) (19% vs. 37%, P < 0.0001). Older patients had more infections during induction (81% vs. 70%, P = 0.05), and drug reductions (46% vs. 28%, P = 0.0009). Among older patients, Ph+ and cytogenetic risk category as well as infection during induction predicted for worse EFS. Poorer outcomes in these patients are partly due to cytogenetic risk, but there is significant morbidity and mortality during induction chemotherapy with frequent delays and drug reductions. New approaches, including better risk stratification and use of targeted therapies, could improve treatment for these patients.


Publication metadata

Author(s): Sive JI, Buck G, Fielding A, Lazarus HM, Litzow MR, Luger S, Marks DI, McMillan A, Moorman AV, Richards SM, Rowe JM, Tallman MS, Goldstone AH

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2012

Volume: 157

Issue: 4

Pages: 463-471

Print publication date: 13/03/2012

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2141.2012.09095.x

DOI: 10.1111/j.1365-2141.2012.09095.x


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