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Roles of c-Rel signalling in inflammation and disease

Lookup NU author(s): Dr Nicola Fullard, Professor Fiona OakleyORCiD

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Abstract

Nuclear factor kappa B (NF kappa B) is a dimeric transcription factor comprised of five family members RelA (p65), RelB, c-Rel, p50 and p52. NF kappa B signalling is complex and controls a myriad of normal cellular functions. However, constitutive or aberrant activation of this pathway is associated with disease progression and cancer in multiple organs. The diverse array of biological responses is modulated by many factors, including the activating stimulus, recruitment of co-regulatory molecules, consensus DNA binding sequence, dimer composition and post-translational modifications. Each subunit has very different biological functions and in the context of disease the individual subunits forming the NF kappa B dimer can have a profound effect, causing a shift in the balance from normal to pathogenic signalling. Here we discuss the role of c-Rel dependant signalling in normal physiology and its contribution to disease both inside and outside of the immune system. (C) 2012 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Fullard N, Wilson CL, Oakley F

Publication type: Review

Publication status: Published

Journal: International Journal of Biochemistry & Cell Biology

Year: 2012

Volume: 44

Issue: 6

Pages: 851-860

Print publication date: 02/03/2012

ISSN (print): 1357-2725

ISSN (electronic): 1878-5875

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

URL: http://dx.doi.org/10.1016/j.biocel.2012.02.017

DOI: 10.1016/j.biocel.2012.02.017

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