Publications by Professor Fiona Oakley - ePrints

Browsing publications by Professor Fiona Oakley.

Newcastle Authors	Title	Year
Professor Fiona Oakley Dr Simon Cockell Dr Olivier Govaere Professor Ann Daly Professor Arun Sanyal et al.	An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)	2024
Dr Aidan Bowes Amy Collins Professor Fiona Oakley Dr Piergiorgio Gentile Dr Ana Ferreira-Duarte et al.	Bioprinted high cell density laminar scaffolds stimulate ECM production in osteochondral co-cultures	2024
Dr Brian Ford Dr Shruti Chachra Ahmed Alshawi Professor Fiona Oakley Professor Dina Tiniakos et al.	Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants	2024
Amy Collins Professor Fiona Oakley Professor Derek Mann	Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	2024
Dr Toni Pringle Erik Ramon Gil Dr Jack Leslie Professor Fiona Oakley Professor Matthew Wright et al.	Synthesis and Preclinical Evaluation of a ⁸⁹Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury	2024
Amy Collins Rebecca Scott Dr Caroline Wilson Dr Giuseppe Abbate Steven White et al.	UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis	2024
Lucy Gee Dr Ben Barron-Millar Dr Marco Zaki Dr Saimir Luli Rachel Burgoyne et al.	Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice	2023
Dr Jack Leslie Dr Jill Hunter Amy Collins Amelia Rushton Lauren Russell et al.	c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis	2023
Bassier Zadran Daniel Wainwright Dr Yvonne Bury Dr Saimir Luli Rachel Howarth et al.	Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation	2023
Laura Sabater Jean-Baptiste Gossart Inmaculada Hernandez Lopez Dr Daniel Rico Rodriguez Dr Lee Borthwick et al.	miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways	2023
Amy Collins Dr Glyn Nelson Professor Fiona Oakley Professor Derek Mann	Sublethal necroptosis signaling promotes inflammation and liver cancer	2023
Dr Riem Gawish Professor Fiona Oakley Dr John Brain	A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4	2022
Dr Suzanne Madgwick Dr Saimir Luli Helene Sellier Dr Jacqueline Butterworth Dr Jack Leslie et al.	Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	2022
Professor Fiona Oakley	Interrogating mechanisms of liver fibrosis with omics	2022
Professor Fiona Oakley	Reply	2022
Professor Fiona Oakley	Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression	2022
Dr Marco Zaki Dr Sari Alhasan Dr Ruchi Shukla Misti McCain Maja Laszczewska et al.	Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?	2022
Dr Tiaan Heunis Dr Jose Luis Marin-Rubio Francesca Cianfanelli Dr Ben Raymond Dr Joe Inns et al.	The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection	2022
Lucy Gee Professor Fiona Oakley	5-HT_2B Receptors in Liver	2021
Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al.	A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis	2021
Marina Barcena-Varela Dr Hannah Paish Stuart Robinson Jeremy French Professor Fiona Oakley et al.	Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: Dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis	2021
Marco Zaki Dr Ahmed Mahdi Dr Gillian Patman Anna Whitehead Joao Mauricio et al.	Key features of the environment promoting liver cancer in the absence of cirrhosis	2021
Dr Jack Leslie Dr Emma Scott Professor Quentin Anstee Professor Fiona Oakley	Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma	2021
Dr Jack Leslie Dr Marie-Helene Ruchaud Amy Collins Leena Habiballa Dr Gabi Saretzki et al.	Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner	2021
Dr Jack Leslie Stuart Robinson Professor Fiona Oakley Dr Saimir Luli	Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging	2021
Dr Jack Leslie Professor Fiona Oakley	Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression	2021
Professor Fiona Oakley Marco Zaki Professor Derek Mann	TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms	2021
Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al.	Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis	2020
Dr Ed Fielder Dr Clare Tweedy Dr Caroline Wilson Professor Fiona Oakley Dr Fiona LeBeau et al.	Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice	2020
Dr Olivier Govaere Dr Dina Tiniakos Professor Quentin Anstee Professor Fiona Oakley	Bone Morphogenic Protein 8B Promotes the Progression of Non-Alcoholic Steatohepatitis	2020
Dr Julie Worrell Dr Jack Leslie Dr Graham Smith Marco Zaki Dr Hannah Paish et al.	cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis	2020
Dr Jack Leslie Dr Marina Garcia Macia Dr Saimir Luli Dr Julie Worrell William Reilly et al.	c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis	2020
Dr Jack Leslie Benjamin Millar Alicia Del Carpio Pons Rachel Burgoyne Joseph Frost et al.	FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis	2020
Professor Fiona Oakley	Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis	2020
Dr Jack Leslie Professor Fiona Oakley	Loss of ELK1 has differential effects on age-dependent organ fibrosis	2020
Dr Alistair Leitch Dr Tarek Mamdouh Abdelghany Dr Alex Charlton Professor Fiona Oakley Dr Lee Borthwick et al.	Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse	2020
Laura Sabater Dr Luigi Locatelli Professor Fiona Oakley Dr Timothy Hardy Jeremy French et al.	RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat	2020
Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al.	A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices	2019
Dr Hannah Paish Lee Reed Abi Watson Dr Jack Leslie Professor Fiona Oakley et al.	Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease	2019
Dr Dumitru Sirbu Dr Saimir Luli Dr Jack Leslie Professor Fiona Oakley Professor Andrew Benniston et al.	Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice using a Highly Bright Near-Infrared BODIPY Dye	2019
Professor Fiona Oakley Lucy Gee Professor Neil Sheerin Dr Lee Borthwick	Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy	2019
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Dr Dina Tiniakos Professor Derek Mann et al.	Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage	2019
Professor Fiona Oakley	Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity	2019
Clara Correia Melo Dr Jodie Birch Dr Ed Fielder Dr James Chapman Dr Anthony Lagnado et al.	Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice	2019
Dr Sameh Abou-Beih Dr Steven Masson Professor Fiona Oakley Dr Dina Tiniakos	Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome	2019
Professor Fiona Oakley	Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway	2018
Dr Mujdat Zeybel Dr Saimir Luli Laura Sabater Dr Timothy Hardy Professor Fiona Oakley et al.	A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A	2017
Professor Fiona Oakley Professor Derek Mann	The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.	2017
Dr Amy Fearn Dr Aldi Situmorang Christopher Fox Professor Fiona Oakley Rachel Howarth et al.	The NF-kB1 is a key regulator of acute but not chronic renal injury	2017
Dr Saimir Luli Dr Stephen Hill Helen Brown Jack Leslie Dr Helen Marshall et al.	A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo	2016
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Jack Leslie Helene Sellier et al.	A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer	2016
Dr Riem Gawish Professor Fiona Oakley Dr John Brain	B-cells and neutrophils promote disease tolerance to murine gram negative sepsis	2016
Dr Sameh Abou-Beih Dr Steven Masson Professor Fiona Oakley Dr Dina Tiniakos	Evaluation of centrilobular fibrosis in post-transplant liver: Preliminary results	2016
Dr Marzena Ciechomska Dr Steven O'Reilly Professor Fiona Oakley Professor Jaap van Laar	Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2	2016
Christopher Fox Dr Pasquale Cocchiaro Professor Fiona Oakley Rachel Howarth Krystena Callaghan et al.	Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease	2016
Dr Timothy Hardy Professor Fiona Oakley Professor Quentin Anstee Professor Chris Day	Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum	2016
Dr Emma Fairhall Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright	Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system.	2016
Stuart Robinson Professor Derek Mann Professor Derek Manas Professor Fiona Oakley Professor Jelena Mann et al.	Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''	2016
Dr Sameh Abou-Beih Dr Steven Masson Dr Beate Haugk Professor Fiona Oakley	Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: Association with histological changes, hepatic stellate cell activation and impact on patient outcome	2016
Professor Fiona Oakley Dr Maria Perugorria Professor Derek Mann	TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury	2016
Dr Phillip Probert Dr Stephanie Meyer Fouzeyyah Alsaeedi Andrew Axon Dr Emma Fairhall et al.	An expandable donor-free supply of functional hepatocytes for toxicology	2015
Professor Fiona Oakley Professor Derek Mann	Chapter 15 - Stellate Cell Depletion Models	2015
Dr Eva Moran Salvador Dr Pier Paoli Dr Graham Smith Dr Agata Page Rachel Howarth et al.	MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Professor Derek Mann Professor Fiona Oakley et al.	Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy	2015
Dr Caroline Wilson Dr Diana Jurk Nicola Fullard Paul Banks Dr Agata Page et al.	NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma	2015
Dr Saimir Luli Dr Daniela Di Paolo Dr Caroline Wilson Professor Matthew Wright Helen Brown et al.	Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice	2015
Christopher Fox Rachel Howarth Krystena Callaghan Dr Katrina Wood Professor Fiona Oakley et al.	Pepstatin A improves renal fibrosis by impairing UPA lysosomal recycling	2015
Dr Luigi Locatelli Dr Pier Paoli Dr Timothy Hardy Rachel Howarth Professor Fiona Oakley et al.	Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation	2015
Aimen Amer Dr Phillip Probert Dr Michael Dunn Margaret Knight Dr Abigail Vallance et al.	Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Dina Tiniakos Professor Derek Mann et al.	Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities	2015
Dr Caroline Wilson Dr Lindsay Murphy Jack Leslie Dr Stuart Kendrick Jeremy French et al.	Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease	2015
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Jelena Mann Professor Alastair Burt et al.	A reversible model for periportal fibrosis and a refined alternative to bile duct ligation	2014
Dr Saimir Luli Dr Stephen Hill Professor Matthew Wright Professor Derek Mann Professor Fiona Oakley et al.	A simple fluorescence based method to non-invasively image liver fibrosis	2014
Dr Anna Moles Fernandez Dr Lindsay Murphy Dr Caroline Wilson Dr Jayshree Bagchi Chakraborty Christopher Fox et al.	A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse	2014
Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al.	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice	2014
Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright	Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells	2014
Dr John Skamarauskas Professor Fiona Oakley Dr Fiona Smith Carlo Bawn Dr Michael Dunn et al.	Non-invasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker	2014
Dr Caroline Wilson Professor Jelena Mann Dr Meagan Walsh Professor Fiona Oakley Professor Matthew Wright et al.	Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3	2014
Dr Steven O'Reilly Rachel Cant Dr Marzena Ciechomska Professor Fiona Oakley Professor Sophie Hambleton et al.	Serum Amyloid A (SAA) induces IL-6 in dermal fibroblasts via TLR2, IRAK4 and NF-κB	2014
Dr Steven O'Reilly Rachel Cant Dr Marzena Ciechomska James Finnigan Professor Fiona Oakley et al.	Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-kappa B	2014
Dr Michelle Charles Dr Karen Wallace Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright et al.	THE glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations	2014
Dr Phillip Probert Git Chung Dr Simon Cockell Professor Loranne Agius Steven White et al.	Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies	2014
Dr Lindsay Murphy Dr Jayshree Bagchi Chakraborty Professor Jelena Mann Professor Fiona Oakley Professor Derek Mann et al.	Deficient Neutrophil Recruitment into the Liver Parenchyma after an Acute CCl₄ Challenge does not affect Fibrogenesis	2013
Dr Lindsay Murphy Dr Saimir Luli Dr Lee Borthwick Dr Steven O'Reilly Professor Neil Perkins et al.	Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response	2013
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann et al.	Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat	2013
Dr Gillian Patman Dr Despina Televantou Anna Whitehead Professor Chris Day Professor Fiona Oakley et al.	Mild Steatosis and Impaired Glucose Tolerance are Associated with Liver Cancer Development, While Progression to Nash Increases Number/Size in an Animal Model of NAFLD	2013
Stuart Robinson Professor Jelena Mann Professor John Mathers Professor Alastair Burt Professor Fiona Oakley et al.	Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model	2013
Professor Derek Mann Professor Fiona Oakley	Serotonin paracrine signaling in tissue fibrosis	2013
Dr Nicola Fullard Dr Steven O'Reilly Professor Jaap Van Laar David Faini Julie Diboll et al.	The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice	2013
Stuart Robinson Professor Derek Mann Professor Derek Manas Professor Fiona Oakley Professor Jelena Mann et al.	The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome	2013
Dr Maria Perugorria Dr Lindsay Murphy Dr Nicola Fullard Dr Caroline Wilson Professor Fiona Oakley et al.	Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice	2013
Professor Fiona Oakley Professor Neil Perkins	BAG-1 interacts with the p50-p50 homodimeric NF-kappa B complex: implications for colorectal carcinogenesis	2012
Dr Maria Perugorria Dr Mujdat Zeybel Mark Walsh Shilu Amin Professor Alastair Burt et al.	Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation	2012
Professor Derek Mann Professor Fiona Oakley	Inhibition of 536 phosphorylation site in NF-kappa B (RELA) reduces liver fibrosis in mouse progressive liver disease, but does not block the innate immune response	2012
Dr Mujdat Zeybel Dr Timothy Hardy Frances Wong Professor John Mathers Christopher Fox et al.	Multigenerational epigenetic adaptation of the hepatic wound-healing response	2012
Dr Caroline Wilson Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	NF-kappa B1-/- suppresses ageing and carcinogen-induced hepatocellular carcinoma by limiting neutrophil accumulation and ROS production	2012
Professor Fiona Oakley Professor Derek Mann Dr Neil Hanley	Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans	2012
Dr Nicola Fullard Professor Fiona Oakley	Roles of c-Rel signalling in inflammation and disease	2012
Silvia Gaspar Pereira Dr Nicola Fullard Aidan Maxwell Dr Lindsay Murphy Dr Ralf Bauer et al.	The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis	2012
Dr Anna Moles Fernandez Professor Fiona Oakley Professor Derek Mann	A peptide mimetic of the functional SER536 phosphorylation site in NF-kappa B (RELA) inhibits liver fibrosis	2011
Dr Maria Perugorria Dr Caroline Wilson Dr Mujdat Zeybel Shilu Amin Professor Fiona Oakley et al.	Expression profiling of epigenetic regulators identifies ASH1 as a key activator of pro-fibrogenic genes	2011
Dr Mujdat Zeybel Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann Professor Jelena Mann et al.	Protective adaptation to liver fibrosis in a single generation by heritable epigenetic modifications	2011
Dr Mohammed Ebrahimkhani Professor Fiona Oakley Dr Lindsay Murphy Professor Jelena Mann Dr Maria Perugorria et al.	Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease	2011
Professor Fiona Oakley Dr Lindsay Murphy Professor Matthew Wright Professor Derek Mann	Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell	2011
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	TREM-2 expression is induced during the regeneration phase of liver injury and acts as a negative regulator of neutrophillic infiltration and hepatocyte proliferation	2011
Dr Caroline Wilson Professor Fiona Oakley Professor Derek Mann	UCH-L1: A novel and functional marker for activated hepatic stellate cells	2011
Andy Axon Dr David Cowie Professor Fiona Oakley Professor Faith Williams Professor Peter Blain et al.	Acute oestradiol (E2) administration to mice results in liver portal tract inflammation	2010
Professor Jelena Mann Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann	Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis	2010
Professor Fiona Oakley Professor Derek Mann Dr Neil Hanley	Identification of SOX9 as a novel mechanism to explain aspects of liver fibrosis	2010
Professor Jelena Mann Aidan Maxwell Professor Fiona Oakley Professor Derek Mann	MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis	2010
Dr Helen Marshall Professor Fiona Oakley Professor Matthew Wright	Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy	2010
Professor Jelena Mann Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann	NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha	2010
Professor Fiona Oakley	SOX9 is a critical regulator of extracellular matrix deposition during liver fibrosis	2010
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Dr Mohammed Ebrahimkhani et al.	The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation	2010
Dr Ahmed Elsharkawy Professor Fiona Oakley Professor Derek Mann Professor Jelena Mann	The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes	2010
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation	2010
Professor Fiona Oakley Dr Martha Watson Professor Derek Manas Professor Derek Mann	Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser⁵³⁶ to Promote Myofibroblast Survival and Liver Fibrosis	2009
Professor Jelena Mann Xin Xu Professor Fiona Oakley Aidan Maxwell Dr Ahmed Elsharkawy et al.	Epigenetically Inherited Resistance to Liver Fibrosis	2009
Dr Lindsay Murphy Dr Mohammed Ebrahimkhani Professor Derek Mann Professor Fiona Oakley	Pharmacological Blockade of 5HT 2B Receptor Stimulates Liver Growth	2009
Dr Roben Gieling Vidya Rajasekaran Dr Diana Jurk Dr Ahmed Elsharkawy Professor Alastair Burt et al.	The Anti-Inflammatory and Anti-Proliferative Properties of the NFKB1 (P50) Gene Protect Against Hepatocellular Carcinoma	2009
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Fiona Oakley Professor Derek Mann et al.	The NF-Kappa B Subunit C-Rel is Involved in Hepatocyte Proliferation in Chronic Injured and Regenerating Liver	2009
Dr Amy Fearn Professor Fiona Oakley Professor Derek Mann Professor Neil Sheerin	Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1	2009
Dr Amy Fearn Professor Fiona Oakley Professor Derek Mann Professor Neil Sheerin	Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1	2009
Dr Ahmed Elsharkawy Dr Roben Gieling Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann et al.	Attenuated inflammatory response in fibrotic livers of mice lacking the c-Rel subunit of NF-kB	2008
Professor Fiona Oakley Dr David Wilson Professor Derek Mann Dr Neil Hanley	Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis	2008
Professor Fiona Oakley Dr Ahmed Elsharkawy Professor Derek Mann	Hepatic nuclear factor κB regulates neutrophil recruitment to the injured brain	2008
Dr Roben Gieling Dr Martha Watson Professor Fiona Oakley Professor Derek Mann	Highly specific inhibitors define a conserved function for NF-kB as a regulator of apoptosis in both human and rodent hepatic stellate cells	2008
Professor Fiona Oakley Professor Albert Geerts	Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells	2008
Dr Martha Watson Dr Karen Wallace Dr Roben Gieling Professor Derek Manas Professor Derek Mann et al.	NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts	2008
Professor Fiona Oakley	Nuclear factor-κB1: Regulation and function	2008
Professor Fiona Oakley Professor Derek Mann	RelA serine 536 phosphorylation could be a biomarker for fibrosis that may be susceptible to regression following attenuatino of renin-angiotensin signaling	2008
Dr Mohammed Ebrahimkhani Professor Derek Mann Professor Fiona Oakley	Serotonin 2B receptor: A novel negative regulator of liver growth	2008
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Professor Fiona Oakley et al.	The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice	2008
Professor Fiona Oakley Dr Martha Watson Professor Derek Mann	The renin angiotensin system as an activator of NF-KB and a survival signal for rat and human hepatic myofibroblasts	2008
Professor Jelena Mann Professor Fiona Oakley Dr Ahmed Elsharkawy Professor Derek Mann	Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis	2007
Professor Fiona Oakley Professor Derek Mann	A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis	2006
Professor Derek Mann Professor Fiona Oakley	An explanation for the apparent cell-selectivity of sulfasalazine as an inducer of hepatic myofibroblast apoptosis	2006
Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation	2006
Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Derek Mann	Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats	2006
Professor Derek Mann Professor Fiona Oakley	Real-time in vivo analysis of NF-kappaB activation reveals a role for the liver as a regulator of acute brain inflammation	2006
Peter Smith Professor Fiona Oakley Professor Derek Mann	Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging	2005
Professor Fiona Oakley Dr Carlyn Marek Professor Matthew Wright Professor Derek Mann	Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis	2005
Professor Derek Mann Professor Fiona Oakley	NF-kappaB: a signal for cancer	2005
Professor Fiona Oakley Professor Derek Mann	Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity	2005
Professor Fiona Oakley Professor Jelena Mann Professor Simi Ali Professor Derek Mann	Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury	2005
Dr Ahmed Elsharkawy Professor Fiona Oakley Professor Derek Mann	The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis	2005
Professor Fiona Oakley	Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.7	2004
Professor Fiona Oakley Professor Derek Mann	Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1	2004
Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1	2003
Professor Fiona Oakley Professor Derek Mann	Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis	2003
Professor Jelena Mann Professor Fiona Oakley Professor Derek Mann	CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells REGULATION BY TRAF2, AP-1, NF-κB, AND CBF1	2002
Clare McCormick Professor Fiona Oakley Professor Derek Mann	High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors	2002