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Segregation of Axonal and Somatic Activity During Fast Network Oscillations

Lookup NU author(s): Professor Miles Whittington

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Abstract

In central neurons, information flows from the dendritic surface toward the axon terminals. We found that during in vitro gamma oscillations, ectopic action potentials are generated at high frequency in the distal axon of pyramidal cells (PCs) but do not invade the soma. At the same time, axo-axonic cells (AACs) discharged at a high rate and tonically inhibited the axon initial segment, which can be instrumental in preventing ectopic action potential back-propagation. We found that activation of a single AAC substantially lowered soma invasion by antidromic action potential in postsynaptic PCs. In contrast, activation of soma-inhibiting basket cells had no significant impact. These results demonstrate that AACs can separate axonal from somatic activity and maintain the functional polarization of cortical PCs during network oscillations.

Publication metadata

Author(s): Dugladze T, Schmitz D, Whittington MA, Vida I, Gloveli T

Publication type: Article

Publication status: Published

Journal: Science

Year: 2012

Volume: 336

Issue: 6087

Pages: 1458-1461

Print publication date: 15/06/2012

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science

URL: http://dx.doi.org/10.1126/science.1222017

DOI: 10.1126/science.1222017

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