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¹H, ¹⁵N and ¹³C backbone chemical shift assignment of the titin A67-A68 domain tandem

Lookup NU author(s): Professor Steve Homans


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Single molecules of the giant protein titin extend across half of the muscle sarcomere, from the Z-line to the M-line, and have roles in muscle assembly and elasticity. In the A-band titin is attached to thick filaments and here the domain arrangement occurs in regular patterns of eleven called the large super-repeat. The large super-repeat itself occurs eleven times and forms nearly half the titin molecule. Interactions of the large super-repeats with myosin are consistent with a role in thick filament assembly. Here we report backbone assignments of the titin A67-A68 domain tandem (Fn-Ig) from the third super-repeat (A65-A75) completed using triple resonance NMR experiments.

Publication metadata

Author(s): Czajlik A, Thompson GS, Khan GN, Kalverda AP, Homans SW, Trinick J

Publication type: Article

Publication status: Published

Journal: Biomolecular NMR Assignments

Year: 2012

Volume: 6

Issue: 1

Pages: 39-41

Print publication date: 21/07/2011

ISSN (print): 1874-2718

ISSN (electronic): 1874-270X

Publisher: Springer Netherlands


DOI: 10.1007/s12104-011-9321-6


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