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Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

Lookup NU author(s): Professor Steve Homans

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Abstract

The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

Publication metadata

Author(s): Bernlind C, Homans SW, Field RA

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 2009

Volume: 50

Issue: 26

Pages: 3397-3399

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.tetlet.2009.02.131

DOI: 10.1016/j.tetlet.2009.02.131

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