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Perspectives on NMR in drug discovery: a technique comes of age

Lookup NU author(s): Professor Steve Homans

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Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

Publication metadata

Author(s): Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G

Publication type: Article

Publication status: Published

Journal: Nature Reviews: Drug Discovery

Year: 2008

Volume: 7

Pages: 738-745

ISSN (print): 1474-1776

ISSN (electronic): 1474-1784

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/nrd2606

DOI: 10.1038/nrd2606

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