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Vitamin D in children with cystic fibrosis

Lookup NU author(s): Dr Malcolm Brodlie, Dr Matthew Thomas, Dr David Spencer


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Purpose The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.Methods PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.Results The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.Conclusions A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.

Publication metadata

Author(s): Brodlie M, Orchard WA, Reeks GA, Pattman S, McCabe H, O'Brien CJ, Thomas MF, Spencer DA

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2012

Volume: 97

Issue: 11

Pages: 982-984

Print publication date: 04/08/2012

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group


DOI: 10.1136/archdischild-2011-301398


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Funder referenceFunder name
G0800419Medical Research Council