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Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

Lookup NU author(s): Professor Ann DalyORCiD, Professor Farhad Kamali


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Genotyping patients for CYP2C9 and VKORC1 polymorphisms can improve the accuracy of dosing during the initiation of anticoagulation with vitamin K antagonists (coumarin derivatives). The anticipated degree of improvement in the safety of anticoagulation with coumarins through genotyping may vary depending on the quality of patient care, which varies both with and among countries. The management and the cost of anticoagulant care can therefore influence the cost effectiveness of genotyping within any given country. In this article, we provide an overview of the cost effectiveness of pharmacogenetics-guided dosing of coumarin derivatives. We describe the organization of anticoagulant care in the UK, Sweden, The Netherlands, Greece, Germany and Austria, where a genotype-guided dosing algorithm is currently being investigated as part of the EU-PACT trial. We also explore the costs of anticoagulant care for the treatment of atrial fibrillation in these countries.

Publication metadata

Author(s): Verhoef TI, Redekop WK, van Schie RMF, Bayat S, Daly AK, Geitona M, Haschke-Becher E, Hughes DA, Kamali F, Levin LA, Manolopoulos VG, Pirmohamed M, Siebert U, Stingl JC, Wadelius M, de Boer A, Maitland-van der Zee AH, EU-PACT Grp

Publication type: Review

Publication status: Published

Journal: Pharmacogenomics

Year: 2012

Volume: 13

Issue: 12

Pages: 1405-1417

Print publication date: 01/09/2012

ISSN (print): 1462-2416

ISSN (electronic): 1744-8042



DOI: 10.2217/PGS.12.124