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Chemokines in transplantation: what can atypical receptors teach us about anti-inflammatory therapy?

Lookup NU author(s): Dr Graeme O'Boyle, Professor Simi Ali, Emeritus Professor John Kirby


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More than 45 members of the family of chemotactic cytokines have been described. These chemokines control the migration of leukocytes throughout the whole alloimmune response from initial ischemic damage to acute inflammation and eventual resolution. Several chemokines have been strongly linked to allograft rejection. Recent studies have described powerful endogenous mechanisms that regulate chemokine biology. This review will describe a new class of chemokine receptor that bind ligands with high affinity but lack the capacity for signaling. Atypical receptors represent a new paradigm in chemokine biology and may hold the key to our eventual manipulation of chemokine-driven allograft inflammation. (C) 2011 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): O'Boyle G, Ali S, Kirby JA

Publication type: Article

Publication status: Published

Journal: Transplantation Reviews

Year: 2011

Volume: 25

Issue: 4

Pages: 136-144

Print publication date: 01/10/2011

ISSN (print): 0955-470X

ISSN (electronic): 1557-9816

Publisher: Elsevier Science


DOI: 10.1016/j.trre.2010.10.005


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Funder referenceFunder name
British Heart Foundation
078892Wellcome Trust
884289934Roche Organ Transplantation Research Fund