Toggle Main Menu Toggle Search

Open Access padlockePrints

Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in ST-segment elevation myocardial infarction

Lookup NU author(s): Dr Mohaned Egred, Dr Alan Bagnall, Professor Ioakim SpyridopoulosORCiD, Sheila Jamieson, Dr Javed Ahmed


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Aims To assess the impact of thrombus aspiration during primary percutaneous coronary intervention (PPCI) on the mortality of patients with ST-elevation myocardial infarction (STEMI) patients. Methods and results Retrospective analysis of prospectively collected data on 2567 consecutive PPCI-treated STEMI patients between 2008 and 2011. Cox proportional hazard models and multiple logistic regression analysis were used to adjust for known covariates. Thrombectomy was performed in 1095 patients (42.7%). Post-PPCI thrombolysis in myocardial infarction 3 flow was more frequently achieved in the thrombectomy group [adjusted odds ratio (OR); 1.92, 95% confidence interval (CI): 1.34-2.76, P = 0.0004]. Overall in-hospital and longer term (mean follow-up 9.9 months) mortality rates were 4.5 and 9.0%, respectively. Thrombectomy was associated with a significant reduction in in-hospital (adjusted OR: 0.51, 95% CI: 0.29-0.93, P = 0.027) and longer term mortality [adjusted hazard ratio (HR): 0.69, 95% CI: 0.48-0.96, P = 0.028]. With propensity weighting, the adjusted HR for longer term mortality for thrombectomy was 0.43 (95% CI: 0.19-0.97; P = 0.042). The association between thrombectomy and reduced longer term mortality was only significant in those with a total ischaemic time = 180 min (P = 0.001) but not in patients with a total ischaemic time.180 min (P = 0.99). Conclusion This study of real-world, unselected STEMI patients demonstrates that thrombus aspiration during PPCI is associated with a significant reduction in mortality, especially in those with a short total ischaemic time. These findings support the use of thrombectomy during PPCI in this group of patients.

Publication metadata

Author(s): Noman A, Egred M, Bagnall A, Spyridopoulos I, Jamieson S, Ahmed J

Publication type: Article

Publication status: Published

Journal: European Heart Journal

Year: 2012

Volume: 33

Issue: 24

Pages: 3054-3061

Print publication date: 17/09/2012

ISSN (print): 0195-668X

ISSN (electronic): 1522-9645

Publisher: Oxford University Press


DOI: 10.1093/eurheartj/ehs309


Altmetrics provided by Altmetric