Browse by author
Lookup NU author(s): Dr Alison Blain, Liz Greally, Dr Steven Laval, Professor Andrew BlamireORCiD, Dr Guy MacGowanORCiD, Professor Volker StraubORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease that affects approximately 1 in 3500 male births. We describe animal models of DMD with special reference to the mdx mouse. We also describe some of the standard operating procedures (SOPs) developed by the TREAT-NMD neuromuscular network (http://www.treat-nmd.eu/) for assessment of the mdx mouse, with a focus on techniques for assessing cardiac function that are used in our lab, including the cardiac conductance catheter. We have also recently developed cardiac MRI as a novel cardiac assessment technique for mouse models of muscular dystrophy. We describe how this technique can be used both in the assessment of ventricular function and in the investigation of the role of abnormal calcium influx in muscular dystrophy-associated cardiomyopathy.
Author(s): Blain A, Greally E, Laval S, Blamire A, MacGowan G, Straub V
Publication type: Article
Publication status: Published
Journal: Biocybernetics and Biomedical Engineering
Year: 2012
Volume: 32
Issue: 4
Pages: 3-15
Print publication date: 01/01/2012
ISSN (print): 0208-5216
ISSN (electronic):
Publisher: Polska Akademia Nauk
URL: http://www.ibib.waw.pl/?act=show&kat=171
