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Torching the Haystack: Modelling fast-fail strategies in drug development

Lookup NU author(s): Dr Dennis LendremORCiD, Dr Clare LendremORCiD


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By quickly clearing the development pipeline of failing or marginal products, fast-fail strategies release resources to focus on more promising molecules. The Quick-Kill model of drug development demonstrates that fast-fail strategies will: (1) reduce the expected time to market; (2) reduce expected R&D costs; and (3) increase R&D productivity. This paper outlines the model and demonstrates the impact of fast-fail strategies. The model is illustrated with costs and risks data from pharmaceutical and biopharmaceutical companies.

Publication metadata

Author(s): Lendrem DW, Lendrem BC

Publication type: Article

Publication status: Published

Journal: Drug Discovery Today

Year: 2013

Volume: 18

Issue: 7-8

Pages: 331-336

Print publication date: 12/12/2012

ISSN (print): 1359-6446

ISSN (electronic): 1878-5832

Publisher: Elsevier


DOI: 10.1016/j.drudis.2012.11.011


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