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The Development Speed Paradox: Can increasing development speed reduce R&D productivity?

Lookup NU author(s): Dr Dennis LendremORCiD, Dr Clare LendremORCiD


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In the 1990s the pharmaceutical industry sought to increase R&D productivity by shifting development tasks into parallel in order to reduce development cycle times and increase development speed. This paper presents a simple model demonstrating that when attrition rates are high, as in pharmaceutical development, such development speed initiatives can increase the expected time for the first successful molecule to complete development. Increasing the development speed of successful molecules may actually reduce R&D productivity – the Development Speed Paradox.

Publication metadata

Author(s): Lendrem D, Lendrem BC

Publication type: Article

Publication status: Published

Journal: Drug Discovery Today

Year: 2014

Volume: 19

Issue: 3

Pages: 209-214

Print publication date: 16/09/2013

ISSN (print): 1741-8364

ISSN (electronic): 1359-6446

Publisher: Elsevier Ltd


DOI: 10.1016/j.drudis.2013.09.002


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