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Protein biosynthesis in mitochondria

Lookup NU author(s): Professor Nikolay ZenkinORCiD



Translation, that is biosynthesis of polypeptides in accordance with information encoded in the genome, is one of the most important processes in the living cell, and it has been in the spotlight of international research for many years. The mechanisms of protein biosynthesis in bacteria and in the eukaryotic cytoplasm are now understood in great detail. However, significantly less is known about translation in eukaryotic mitochondria, which is characterized by a number of unusual features. In this review, we summarize current knowledge about mitochondrial translation in different organisms while paying special attention to the aspects of this process that differ from cytoplasmic protein biosynthesis.

Publication metadata

Author(s): Kuzmenko AV, Levitskii SA, Vinogradova EN, Atkinson GC, Hauryliuk V, Zenkin N, Kamenski PA

Publication type: Article

Publication status: Published

Journal: Biochemistry (Moscow)

Year: 2013

Volume: 78

Issue: 8

Pages: 855-866

Print publication date: 01/08/2013

Date deposited: 11/09/2013

ISSN (print): 0006-2979

ISSN (electronic): 1608-3040

Publisher: MAIK Nauka - Interperiodica


DOI: 10.1134/S0006297913080014


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Funder referenceFunder name
Archimedes Foundation
Russian Foundation for Basic Research
"U.M.N.I.K" program
European Regional Development Fund (RLOTITIPP)
International Associated Laboratory "RNA-mitocure"
UK Biotechnology and Biosciences Research Council
8817Russian Ministry of Education and Science
ERC-2007-StG 202994-MTPEuropean Research Council
ETF9012Estonian Science Foundation
ETF9020Estonian Science Foundation
MJD99European Social Fund
PUT37Estonian Science Foundation