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Primary sleep disorders can cause long-term sleep disturbance in patients with autoimmune mediated limbic encephalitis

Lookup NU author(s): Dr Kirstie Anderson, Dr Thomas Kelly, Professor Tim GriffithsORCiD


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Objectives: Antibody mediated limbic encephalitis causes a sub acute encephalopathy with an amnestic syndrome, seizures and often an affective prodrome. Sleep disturbance including abnormal dream sleep and insomnia are described in a percentage of long-term survivors but there are very few detailed assessments of sleep disturbance in patients beyond the acute phase of illness. The objectives of this study were to understand the causes of sleep disturbance in the long-term survivors of antibody mediated limbic encephalitis. Patients and methods: We screened twelve patients under long-term follow up with sleep questionnaires and went on to perform detailed sleep studies (polysomnography) in those who reported sleep disturbance. Results: Two were found to have persistent, severe central and obstructive sleep apnoea and two others to have restless legs and periodic limb movements of sleep. Conclusions: This highlights the need to investigate sleep disturbance in this group of patients. Effective treatments may be available to improve quality of life and daytime function. (C) 2012 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Anderson KN, Kelly TP, Griffiths TD

Publication type: Article

Publication status: Published

Journal: Clinical Neurology and Neurosurgery

Year: 2013

Volume: 115

Issue: 7

Pages: 1079-1082

Print publication date: 21/11/2012

ISSN (print): 0303-8467

ISSN (electronic): 1872-6968

Publisher: Elsevier BV


DOI: 10.1016/j.clineuro.2012.10.031


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Funder referenceFunder name
091593Wellcome Trust
091681Wellcome Trust