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Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains

Lookup NU author(s): Dr Adriana Badarau, Dr Arnaud Basle, Dr Susan Firbank, Professor Christopher Dennison


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The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.

Publication metadata

Author(s): Badarau A, Basle A, Firbank SJ, Dennison C

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2013

Volume: 49

Issue: 73

Pages: 8000-8002

Print publication date: 25/07/2013

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: RSC Publications


DOI: 10.1039/c3cc42709a


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Funder referenceFunder name
BB/E016529Biotechnology and Biological Sciences Research Council (BBSRC)