Lookup NU author(s): Dr Luca Miele,
Professor Chris Day
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There is increasing evidence for a correlation between intestinal microbiota, bacterial translocation and hepatic steatosis. Intestinal microbiota affects nutrient absorption and energy homeostasis. Altered intestinal permeability may favor the passage of bacteria-derived compounds into systemic circulation, causing a systemic inflammatory state, characteristic of the metabolic syndrome. The interaction between intestinal permeability and luminal bacteria is involved in the pathogenesis and evolution of non-alcoholic liver disease. Microbiota pharmacological modulation could be a promising tool for a new therapeutical approach to non-alcoholic fatty liver disease.
Author(s): Miele L, Marrone G, Lauritano C, Cefalo C, Gasbarrini A, Day C, Grieco A
Publication type: Article
Publication status: Published
Journal: Current Pharmaceutical Design
Print publication date: 31/08/2013
ISSN (print): 1381-6128
ISSN (electronic): 1873-4286
Publisher: Bentham Science Publishers Ltd
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