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Lookup NU author(s): Dr Ahmed Elsharkawy, Dr Ulrich Schwab, Dr Brendan McCarron, Professor Alastair BurtORCiD, Professor Ann DalyORCiD, Dr Steven MassonORCiD
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Highly active antiretroviral therapy has revolutionised HIV management. However, many of these drugs are potentially hepatotoxic. Here, we report the first adult case of efavirenz induced acute liver failure successfully treated by liver transplantation. Furthermore, genetic analysis revealed our patient to be a slow efavirenz metaboliser, contributing to the severity of clinical presentation. (C) 2013 Elsevier B. V. All rights reserved.
Author(s): Elsharkawy AM, Schwab U, McCarron B, Burt AD, Daly AK, Hudson M, Masson S
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Virology
Year: 2013
Volume: 58
Issue: 1
Pages: 331-333
Print publication date: 11/06/2013
ISSN (print): 1386-6532
ISSN (electronic): 1873-5967
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/j.jcv.2013.05.003
DOI: 10.1016/j.jcv.2013.05.003
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