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A Dynamic System for the Analysis of Acoustic Features and Valence of Aversive Sounds in the Human Brain

Lookup NU author(s): Dr Sukhbinder Kumar, Dr Katherina von Kriegstein, Professor Tim GriffithsORCiD


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Certain sounds, for example, the squeal of chalk on a blackboard, are perceived as highly unpleasant. Functional magnetic resonance imaging (fMRI) in humans shows responses in the amygdala and auditory cortex to aversive sounds. Dynamic causal modelling (DCM) of the interaction between auditory cortex and the amygdala revealed that evoked responses to aversive sounds are relayed to the amygdala via the auditory cortex. There is a complex interaction between the auditory cortex and amygdala involving effective connectivity in both directions. While acoustic features modulate forward connections from auditory cortex to the amygdala, the valence modulates effective connectivity from the amygdala to the auditory cortex. The results support interaction between the auditory cortex and amygdala where stimuli are first processed to a higher (object) level in the auditory cortex before assignment of valence in the amygdala.

Publication metadata

Author(s): Kumar S, von Kriegstein K, Friston KJ, Griffiths TD

Editor(s): Brian C. J. Moore, Roy D. Patterson, Ian M. Winter, Robert P. Carlyon, Hedwig E. Gockel

Publication type: Book Chapter

Publication status: Published

Book Title: Basic Aspects of Hearing: Physiology and Perception

Year: 2013

Volume: 787

Pages: 463-472

Print publication date: 01/01/2013

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer

Place Published: New York


DOI: 10.1007/978-1-4614-1590-9_51

Library holdings: Search Newcastle University Library for this item

ISBN: 9781461415909