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Lookup NU author(s): Dr Sukhbinder Kumar,
Dr Katherina von Kriegstein,
Professor Tim Griffiths
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Certain sounds, for example, the squeal of chalk on a blackboard, are perceived as highly unpleasant. Functional magnetic resonance imaging (fMRI) in humans shows responses in the amygdala and auditory cortex to aversive sounds. Dynamic causal modelling (DCM) of the interaction between auditory cortex and the amygdala revealed that evoked responses to aversive sounds are relayed to the amygdala via the auditory cortex. There is a complex interaction between the auditory cortex and amygdala involving effective connectivity in both directions. While acoustic features modulate forward connections from auditory cortex to the amygdala, the valence modulates effective connectivity from the amygdala to the auditory cortex. The results support interaction between the auditory cortex and amygdala where stimuli are first processed to a higher (object) level in the auditory cortex before assignment of valence in the amygdala.
Author(s): Kumar S, von Kriegstein K, Friston KJ, Griffiths TD
Editor(s): Brian C. J. Moore, Roy D. Patterson, Ian M. Winter, Robert P. Carlyon, Hedwig E. Gockel
Publication type: Book Chapter
Publication status: Published
Book Title: Basic Aspects of Hearing: Physiology and Perception
Print publication date: 01/01/2013
Series Title: Advances in Experimental Medicine and Biology
Place Published: New York
Library holdings: Search Newcastle University Library for this item