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Lookup NU author(s): Dr Lindi Chen
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Neuroblastoma is an embryonal malignancy of the developing neural crest. Despite improvements in treatment, prognoses remain dire for patients with high-risk disease. Interest in this enigmatic cancer has led to a rapidly changing research landscape and we report on the recent advances in four themes that were discussed at the 3rd Neuroblastoma Research Symposium: (1) The epigenetic signature of neuroblastoma and the epigenetic control of tumour development, (2) novel approaches to targeting MYCN, (3) valuable in vivo modelling and (4) improving differentiation therapies based on a knowledge of normal sympathetic neuron development. Through lively discussion, the development of combined therapies with synergistic effects for which we have a good mechanistic understanding emerged as offering greatest promise. Drug synergies enhance efficacy but also specificity, the latter crucial for reducing long-term side effects in young children. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Author(s): Bell E, Chen L, Viprey VF, Blanchard GB
Publication type: Article
Publication status: Published
Journal: Pediatric Blood & Cancer
Print publication date: 01/09/2014
Online publication date: 07/05/2014
Acceptance date: 07/04/2014
Date deposited: 02/06/2014
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
Publisher: John Wiley & Sons, Inc.
PubMed id: 24803179
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