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Meeting report: 3rd Neuroblastoma Research Symposium, Liverpool, 6-7th November, 2013

Lookup NU author(s): Dr Lindi Chen

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Abstract

Neuroblastoma is an embryonal malignancy of the developing neural crest. Despite improvements in treatment, prognoses remain dire for patients with high-risk disease. Interest in this enigmatic cancer has led to a rapidly changing research landscape and we report on the recent advances in four themes that were discussed at the 3rd Neuroblastoma Research Symposium: (1) The epigenetic signature of neuroblastoma and the epigenetic control of tumour development, (2) novel approaches to targeting MYCN, (3) valuable in vivo modelling and (4) improving differentiation therapies based on a knowledge of normal sympathetic neuron development. Through lively discussion, the development of combined therapies with synergistic effects for which we have a good mechanistic understanding emerged as offering greatest promise. Drug synergies enhance efficacy but also specificity, the latter crucial for reducing long-term side effects in young children. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.

Publication metadata

Author(s): Bell E, Chen L, Viprey VF, Blanchard GB

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2014

Volume: 61

Issue: 9

Pages: 1711-1713

Print publication date: 01/09/2014

Online publication date: 07/05/2014

Acceptance date: 07/04/2014

Date deposited: 02/06/2014

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.25087

DOI: 10.1002/pbc.25087

PubMed id: 24803179

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