Lookup NU author(s): Dr Andrew Best,
Mahsa Kheirollahi Kouhestani,
Dr Marina Danilenko,
Dr Ingrid Ehrmann,
Dr Alison Tyson-Capper,
Professor David Elliott
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Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.
Author(s): Best A, Dalgliesh C, Kheirollahi-Kouhestani M, Danilenko M, Ehrmann I, Tyson-Capper AJ, Elliott DJ
Publication type: Review
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/08/2014
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752