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Tra2 protein biology and mechanisms of splicing control

Lookup NU author(s): Dr Andrew Best, Caroline Dalgliesh, Mahsa Kheirollahi Kouhestani, Dr Marina Danilenko, Dr Ingrid Ehrmann, Professor Alison Tyson-Capper, Professor David Elliott


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Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.

Publication metadata

Author(s): Best A, Dalgliesh C, Kheirollahi-Kouhestani M, Danilenko M, Ehrmann I, Tyson-Capper AJ, Elliott DJ

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2014

Volume: 42

Issue: 4

Pages: 1152-1158

Print publication date: 01/08/2014

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752


DOI: 10.1042/BST20140075