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Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study

Lookup NU author(s): Professor Alison Yarnall, Dr Gordon Duncan, Dr Shirley ColemanORCiD, Dr Michael FirbankORCiD, Professor Gavin Hudson, Professor Patrick Chinnery, Professor John O'Brien, Professor David BrooksORCiD, Ruth Barker, Professor David BurnORCiD

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Abstract

Objective:To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.Methods:Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.Results:The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal -amyloid 1-42 levels ( standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower -amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.Conclusions:In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal -amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

Publication metadata

Author(s): Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2014

Volume: 82

Issue: 4

Pages: 308-316

Print publication date: 20/12/2013

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1212/WNL.0000000000000066

DOI: 10.1212/WNL.0000000000000066

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