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Browsing publications by Professor David Brooks.

Newcastle AuthorsTitleYearFull text
Dr Hilmar Sigurdsson
Dr Alison Yarnall
Dr Brook Galna
Dr Susan Lord
Dr Lisa Alcock
et al.
Gait-related metabolic covariance networks at rest in Parkinson’s disease2022
Professor David Brooks
In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study2022
Professor David Brooks
Spontaneous Partial Recovery of Striatal Dopaminergic Uptake Despite Nigral Cell Loss in Asymptomatic MPTP-Lesioned Female Minipigs2022
Professor David Brooks
Trial of Cinpanemab in Early Parkinson Disease2022
Professor David Brooks
Activated N-methyl-D-aspartate receptor ion channels detected in focal epilepsy with [18F]GE-179 positron emission tomography2021
Professor Nicola Pavese
Professor David Brooks
Brain microglial activation increased in glucocerebrosidase (GBA1) mutation carriers2021
Professor David Brooks
Dr Clive Ballard
Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?2021
Professor David Brooks
­­Exercise protects synaptic density in a rat model of Parkinson’s disease2021
Professor David Brooks
Future imaging in dementia2021
Professor David Brooks
Imaging Familial and Sporadic Neurodegenerative Disorders associated with Parkinsonism2021
Professor David Brooks
Professor Nicola Pavese
Impaired cerebral microcirculation in isolated rapid eye movement sleep behaviour disorder2021
Professor David Brooks
Professor Nicola Pavese
Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: a [11C]-PHNO PET study2021
Professor David Brooks
In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET2021
Professor David Brooks
Professor Nicola Pavese
Monocyte markers correlate with immune and neuronal brain changes in REM Sleep Behaviour Disorder2021
Professor David Brooks
Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum2021
Professor David Brooks
NMDA receptor ion channel activation detected in vivo with [18F]GE-179 PET after electrical stimulation of rat hippocampus2021
Professor David Brooks
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats2021
Professor Nicola Pavese
Professor David Brooks
Preserved noradrenergic function in Parkinson´s disease patients with rest tremor2021
Dr Kirstie Anderson
Dr Rachael Lawson
Professor David Brooks
Professor Nicola Pavese
Progression of sleep disturbances in Parkinson’s Disease. A 5-year longitudinal study.2021
Professor David Brooks
Reduced synaptic density in patients with Lewy body dementia: an [11C]UCB-J PET imaging study2021
Professor David Brooks
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease2021
Dr Jacopo Pasquini
Professor David Brooks
Professor Nicola Pavese
The cholinergic brain in Parkinson’s disease2021
Professor David Brooks
Activation of NMDA Receptor Ion Channels by Deep Brain Simulation in the Pig Visualised with[18F]GE-179 PET2020
Professor Nicola Pavese
Professor David Brooks
Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder – a PET study2020
Professor David Brooks
Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias2020
Professor Nicola Pavese
Professor David Brooks
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study2020
Professor Nicola Pavese
Professor David Brooks
Brain-first vs. Body-first Parkinson’s disease: a multi-modal imaging case-control study2020
Professor David Brooks
Can autonomic testing and imaging contribute to the early diagnosis of MSA? A systematic review and recommendations by the MDS multiple system atrophy (MoDiMSA) study group2020
Professor David Brooks
Professor Nicola Pavese
Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder2020
Professor David Brooks
Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder2020
Professor David Brooks
EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.02020
Professor David Brooks
Erratum: Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study) (Trials (2019) 20 1 (191))2020
Professor David Brooks
Professor Nicola Pavese
Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers2020
Rokiah Ismail
Professor David Brooks
Impaired Perfusion And Capillary Dysfunction In Prodromal Alzhemer’s Disease2020
Professor David Brooks
Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease2020
Professor David Brooks
Preclinical PET Studies of [11C]UCB-J Binding in Minipig Brain2020
Professor David Brooks
Tau Tangles in Parkinson’s Disease: A 2-Year Follow-Up Flortaucipir PET Study2020
Professor David Brooks
The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study2020
Professor David Brooks
Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB‐PET Threshold2019
Professor David Brooks
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease2019
Professor David Brooks
Attenuation of dopamine-induced GABA release in problem gamblers2019
Dr Rory Durcan
Dr Lou Wiblin
Professor Lynn Rochester
Professor David Brooks
Professor David Burn
et al.
Clinical implications of early caudate dysfunction in Parkinson’s disease2019
Professor David Brooks
Comment on "In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"2019
Professor David Brooks
Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter2019
Professor David Brooks
Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis2019
Professor David Brooks
Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: Study protocol for a randomised controlled trial (ELAD study)2019
Rob Atkinson
Professor David Brooks
Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume2019
Dr Rory Durcan
Dr Lou Wiblin
Dr Rachael Lawson
Dr Tien Kheng Khoo
Dr Alison Yarnall
et al.
Prevalence and duration of non‐motor symptoms in prodromal Parkinson's disease2019
Professor David Brooks
Professor Nicola Pavese
Progressive loss of raphe nuclei serotonin transporter in early Parkinson’s disease: a longitudinal 123I-FP-CIT SPECT study2019
Professor David Brooks
Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects2019
Professor David Brooks
Widespread microglial activation in multiple system atrophy2019
Professor David Brooks
Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients2018
Professor David Brooks
Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study2018
Professor David Brooks
Evaluation of the noradrenergic system in Parkinson’s disease: an 11C-MeNER PET and neuromelanin MRI study2018
Professor David Brooks
Professor Nicola Pavese
Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder2018
Professor David Brooks
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein2018
Professor Nicola Pavese
Professor David Brooks
In vivo staging of pathology in REM Sleep Behaviour Disorder – a multi-modality imaging case-control study2018
Dr Michael Firbank
Dr Rachael Lawson
Dr Alison Yarnall
Professor David Brooks
Professor David Burn
et al.
Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study2018
Professor David Brooks
MAO-B Inhibitors Do Not Block In Vivo Flortaucipir ([18F]-AV-1451) Binding2018
Professor David Brooks
Microglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease2018
Professor David Brooks
Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs2018
Professor David Brooks
Observations on REM sleep without atonia assessed with a semi-automated scoring algorithm2018
Dr Dag Aarsland
Professor David Brooks
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease2018
Johann Pasquier
Professor David Brooks
Professor Nicola Pavese
Progression of tremor in early stages of Parkinson’s disease: a clinical and neuroimaging study 2018
Professor David Brooks
Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting2018
Professor David Brooks
Role of neuroinflammation in Alzheimer’s trajectory and in vivo quantification using PET2018
Professor David Brooks
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?2018
Professor David Brooks
Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-minute acquisitions essential?2018
Professor David Brooks
The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease2018
Professor David Brooks
The future of brain imaging in Parkinson’s disease2018
Professor David Brooks
Professor Nicola Pavese
Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study2017
Professor Nicola Pavese
Professor David Brooks
Brain inflammation accompanies amyloid in a majority of mild cognitive impairment cases due to Alzheimer’s disease2017
Dr Michael Firbank
Dr Alison Yarnall
Dr Rachael Lawson
Dr Gordon Duncan
Dr Tien Kheng Khoo
et al.
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease: ICICLE-PD study2017
Professor David Brooks
In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography2017
Dr Luis Peraza Rodriguez
Dr Rachael Lawson
Dr Gordon Duncan
Dr Alison Yarnall
Dr Michael Firbank
et al.
Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment2017
Dr Michael Firbank
Dr Rachael Lawson
Dr Alison Yarnall
Dr Gordon Duncan
Dr Tien Kheng Khoo
et al.
Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease2017
Professor David Burn
Professor David Brooks
Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy2017
Professor David Brooks
Suspected non Alzheimer's pathology – Is it non-Alzheimer's or non-amyloid?2017
Professor Nicola Pavese
Professor David Brooks
Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients2017
Professor David Brooks
Validation of an electronic image reader training programme for interpretation of [18F]flutemetamol β-amyloid PET brain images2017
Professor David Brooks
In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET2016
Dr Gordon Duncan
Dr Michael Firbank
Dr Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?2016
Professor David Burn
Professor David Brooks
Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease2016
Professor David Brooks
Imaging Synucleinopathies2016
Professor David Brooks
Imaging Systemic Dysfunction in Parkinson's Disease2016
Professor David Brooks
Molecular imaging of dopamine transporters2016
Dr Luis Peraza Rodriguez
Dr Rachael Lawson
Dr Michael Firbank
Dr Alison Yarnall
Professor David Brooks
et al.
Principal component discriminant analysis of mild cognitive impairment in Parkinson’s disease reveals early functional changes in the resting state2016
Professor David Brooks
Professor Nicola Pavese
Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease2016
Dr Alison Yarnall
Dr Rachael Lawson
Dr Gordon Duncan
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson's Disease?2015
Dr Michael Firbank
Dr Rachael Lawson
Dr Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study2015
Dr Rachael Lawson
Dr Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
Professor David Burn
et al.
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study2015
Dr Alison Yarnall
Dr Gordon Duncan
Dr Shirley Coleman
Dr Michael Firbank
Dr Gavin Hudson
et al.
Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study2014
Dr Gordon Duncan
Dr Tien Khoo
Dr Alison Yarnall
Dr Michael Firbank
Professor Patrick Chinnery
et al.
Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study2014
Dr Tien Khoo
Dr Alison Yarnall
Dr Gordon Duncan
Dr Shirley Coleman
Professor John O'Brien
et al.
The spectrum of nonmotor symptoms in early Parkinson disease2013
Dr Alison Yarnall
Dr Tien Khoo
Dr Gordon Duncan
Professor David Brooks
Professor David Burn
et al.
Anti-cholinergic load: Is there a cognitive cost in early Parkinson’s disease?2012
Dr Tien Kheng Khoo
Dr Gordon Duncan
Dr Alison Yarnall
Professor David Brooks
Professor John O'Brien
et al.
Apathy in incident Parkinson’s disease2012
Dr Alison Yarnall
Professor Lynn Rochester
Dr Gordon Duncan
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Cholinergic dysfunction in Parkinson’s disease with mild cognitive impairment: a short latency afferent inhibition study2012
Dr Gordon Duncan
Dr Tien Kheng Khoo
Dr Alison Yarnall
Professor John O'Brien
Professor David Brooks
et al.
Elevated homocysteine levels and cognitive dysfunction in an incident cohort of non-demented Parkinson’s disease patients.2012
Professor David Brooks
Professor David Burn
Updated guidelines for the management of Parkinson's disease2001