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Liver transplantation for acute liver failure caused by macrophage activation syndrome

Lookup NU author(s): Dr James Orr, Dr Yvonne BuryORCiD, Dr Mark Hudson, Dr Steven MassonORCiD


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Macrophage activation syndrome (MAS) is a rare, potentially fatal condition, which most frequently complicates rheumatological conditions and is often associated with liver dysfunction. In this case report of a patient with MAS, acute liver failure developed despite conventional immunosuppressive therapy. Liver transplantation resulted in rapid recovery and the patient has remained well for six years. A recent diagnosis of Adult Onset Still's Disease (AOSD) provides additional supporting evidence that the initial presentation was caused by MAS. While transplantation in the context of systemic disease remains controversial, this first reported case of successful adult liver transplantation for acute liver failure caused by MAS raises an interesting clinical dilemma.

Publication metadata

Author(s): Orr J, Bury Y, Hudson M, Masson S

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2013

Volume: 26

Issue: 11

Pages: e105-e108

Print publication date: 01/11/2013

Online publication date: 24/08/2013

Acceptance date: 27/07/2013

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell


DOI: 10.1111/tri.12176


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