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Lookup NU author(s): Dr Thomas Cope, Dr Manon Grube, Freya Cooper, Professor David BurnORCiD, Professor Tim GriffithsORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Bilateral, high-frequency stimulation of the basal ganglia (STN-DBS) is in widespread use for the treatment of the motor symptoms of Parkinson's disease (PD). We present here the first psychophysical investigation of the effect of STN-DBS upon perceptual timing in the hundreds of milliseconds range, with both duration-based (absolute) and beat-based (relative) tasks; 13 patients with PD were assessed with their STN-DBS 'on', `off', and then 'on' again.Paired parametric analyses revealed no statistically significant differences for any task according to DBS status. We demonstrate, from the examination of confidence intervals, that any functionally relevant effect of STN-DBS on relative perceptual timing is statistically unlikely. For absolute, duration-based timing, we demonstrate that the activation of STN-DBS may either worsen performance or have no effect, but that it is unlikely to lead to significant improvement.Although these results are negative they have important implications for our understanding of perceptual timing and its relationship to motor functions within the timing network of the brain. They imply that the mechanisms involved in the perceptual processing of temporal information are likely to be functionally independent from those that underpin movement. Further, they suggest that the connections between STN and the subtantia nigra and globus pallidus are unlikely to be critical to beat-based perceptual timing. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Author(s): Cope TE, Grube M, Mandal A, Cooper FE, Brechany U, Burn DJ, Griffiths TD
Publication type: Article
Publication status: Published
Journal: Neuropsychologia
Year: 2014
Volume: 57
Pages: 29-37
Print publication date: 01/05/2014
Online publication date: 05/03/2014
Acceptance date: 22/02/2014
Date deposited: 29/08/2014
ISSN (print): 0028-3932
ISSN (electronic): 1873-3514
Publisher: Pergamon Press
URL: http://dx.doi.org/10.1016/j.neuropsychologia.2014.02.021
DOI: 10.1016/j.neuropsychologia.2014.02.021
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