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Stem Cells as New Agents for the Treatment of Infertility: Current and Future Perspectives and Challenges

Lookup NU author(s): Professor Majlinda LakoORCiD, Professor Miodrag Stojkovic



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Stem cells are undifferentiated cells that are present in the embryonic, fetal, and adult stages of life and give rise to differentiated cells that make up the building blocks of tissue and organs. Due to their unlimited source and high differentiation potential, stem cells are considered as potentially new therapeutic agents for the treatment of infertility. Stem cells could be stimulated in vitro to develop various numbers of specialized cells including male and female gametes suggesting their potential use in reproductive medicine. During past few years a considerable progress in the derivation of male germ cells from pluripotent stem cells has been made. In addition, stem cell-based strategies for ovarian regeneration and oocyte production have been proposed as future clinical therapies for treating infertility in women. In this review, we summarized current knowledge and present future perspectives and challenges regarding the use of stem cells in reproductive medicine.

Publication metadata

Author(s): Volarevic V, Bojic S, Nurkovic J, Volarevic A, Ljujic B, Arsenijevic N, Lako M, Stojkovic M

Publication type: Review

Publication status: Published

Journal: BioMed Research International

Year: 2014

Pages: 1-8

Print publication date: 14/04/2014

Online publication date: 14/04/2014

Acceptance date: 17/03/2014

ISSN (print): 2314-6133

ISSN (electronic): 2314-6141



DOI: 10.1155/2014/507234