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Lookup NU author(s): Dr Laura Jopson,
Dr Jess Dyson,
Professor David Jones
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Primary biliary cirrhosis, (PBC) is an, autoimmune cholestatic liver disease. Susceptibility to PBC probably arises from a combination of genetic and environmental factors. The. prevalence of PBC varies, both on an international and a regional level. This can be explained, in part, by differences in-clinical practice and case-finding activity. It is likely, however that substantive geographical differences exist both in terms of,genetic, susceptibility and environmental factors that potentially trigger the disease in genetically Susceptible individuals. The study of the epidemiology of PBC has strongly,supported the concept of-an environmental triggering factor, but as yet no specific agent has been identified. Ongoing work to discover the environmental agent, as well as the mechanism that causes the disease Will answer key questions as-to-the epidemiology Of this complex autoimmune disease, as well as providing useful information for other autoimmune conditions.
Author(s): Griffiths L, Dyson JK, Jones DEJ
Publication type: Review
Publication status: Published
Journal: Seminars in Liver Disease
Print publication date: 01/08/2014
ISSN (print): 0272-8087
ISSN (electronic): 1098-8971
Publisher: THIEME MEDICAL PUBL INC