Toggle Main Menu Toggle Search

Open Access padlockePrints

The New Epidemiology of Primary Biliary Cirrhosis

Lookup NU author(s): Dr Laura Jopson, Dr Jess Dyson, Professor David Jones


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Primary biliary cirrhosis, (PBC) is an, autoimmune cholestatic liver disease. Susceptibility to PBC probably arises from a combination of genetic and environmental factors. The. prevalence of PBC varies, both on an international and a regional level. This can be explained, in part, by differences in-clinical practice and case-finding activity. It is likely, however that substantive geographical differences exist both in terms of,genetic, susceptibility and environmental factors that potentially trigger the disease in genetically Susceptible individuals. The study of the epidemiology of PBC has strongly,supported the concept of-an environmental triggering factor, but as yet no specific agent has been identified. Ongoing work to discover the environmental agent, as well as the mechanism that causes the disease Will answer key questions as-to-the epidemiology Of this complex autoimmune disease, as well as providing useful information for other autoimmune conditions.

Publication metadata

Author(s): Griffiths L, Dyson JK, Jones DEJ

Publication type: Review

Publication status: Published

Journal: Seminars in Liver Disease

Year: 2014

Volume: 34

Issue: 3

Pages: 318-328

Print publication date: 01/08/2014

ISSN (print): 0272-8087

ISSN (electronic): 1098-8971



DOI: 10.1055/s-0034-1383730