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Lookup NU author(s): Professor Anthony Moorman
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We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis subgroup of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76.7% vs. 84.6%, P = 0.2) and overall survival (82.4% vs. 90.9%, P = 0.1), and a higher relapse rate (18.6% vs. 9.6%, P = 0.1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.
Author(s): Patrick K, Wade R, Goulden N, Mitchell C, Moorman AV, Rowntree C, Jenkinson S, Hough R, Vora A
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Print publication date: 01/08/2014
Online publication date: 08/04/2014
Acceptance date: 04/03/2014
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
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