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Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Lookup NU author(s): Professor Anthony MoormanORCiD

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Abstract

We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis subgroup of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76.7% vs. 84.6%, P = 0.2) and overall survival (82.4% vs. 90.9%, P = 0.1), and a higher relapse rate (18.6% vs. 9.6%, P = 0.1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

Publication metadata

Author(s): Patrick K, Wade R, Goulden N, Mitchell C, Moorman AV, Rowntree C, Jenkinson S, Hough R, Vora A

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2014

Volume: 166

Issue: 3

Pages: 421-424

Print publication date: 01/08/2014

Online publication date: 08/04/2014

Acceptance date: 04/03/2014

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/bjh.12882

DOI: 10.1111/bjh.12882

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