Toggle Main Menu Toggle Search

Open Access padlockePrints

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Lookup NU author(s): Professor Anthony Moorman

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis subgroup of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76.7% vs. 84.6%, P = 0.2) and overall survival (82.4% vs. 90.9%, P = 0.1), and a higher relapse rate (18.6% vs. 9.6%, P = 0.1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.


Publication metadata

Author(s): Patrick K, Wade R, Goulden N, Mitchell C, Moorman AV, Rowntree C, Jenkinson S, Hough R, Vora A

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2014

Volume: 166

Issue: 3

Pages: 421-424

Print publication date: 01/08/2014

Online publication date: 08/04/2014

Acceptance date: 04/03/2014

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/bjh.12882

DOI: 10.1111/bjh.12882


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share