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Response to Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination"

Lookup NU author(s): Dr Soren Nielsen, Professor Nikolay ZenkinORCiD


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Arimbasseri et al., in their Comment, suggest that to terminate transcription in vivo, RNA polymerase III uses a mechanism other than hairpin-dependent termination and that properties of purified polymerase may depend on preparation procedure. Evidence suggests that our preparation is indeed different from that of other methods. Our new data suggest that, apart from hairpin-dependent termination, one or more "fail-safe" termination mechanisms may exist in the cell.

Publication metadata

Author(s): Nielsen S, Zenkin N

Publication type: Editorial

Publication status: Published

Journal: Science

Year: 2014

Volume: 345

Issue: 6196

Pages: 524-524

Print publication date: 01/08/2014

Acceptance date: 30/06/2014

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science


DOI: 10.1126/science.1254246