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Lookup NU author(s): Dr Frida Ponthan
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BACKGROUND: We reported previously that nearly all human neuroblastomas analyzed contain and express genomic DNA sequences deriving from the human polyomavirus BK (BKV) [Flaegstad et al.: Cancer Res 59:1160-1163, 1999]. PROCEDURE: Here we show that the BKV large T antigen is expressed and bound to p53 in neuroblastoma cells and that this interference compromises the tumor suppressor function of p53. RESULTS: Treatment of neuroblastoma cells with large T antigen antisense constructs relocated active p53 to the nucleus. The relocation event was accompanied by enhanced p21(waf1/cip1) expression as well as induced apoptosis. CONCLUSIONS: Continuous antisense oligonucleotide treatment of nude rats with human neuroblastoma xenografts resulted in a significant but incomplete reduction of tumor growth compared to rats treated with saline.
Author(s): Jørgensen GE, Johnsen JI, Ponthan FM, Kogner P, Flægstad T, Traavik T
Publication type: Article
Publication status: Published
Journal: Medical and Pediatric Oncology
Year: 2000
Volume: 35
Issue: 6
Pages: 593-596
ISSN (print): 0098-1532
URL: http://dx.doi.org/10.1002/1096-911X(20001201)35:6<593::AID-MPO22>3.0.CO;2-I
DOI: 10.1002/1096-911X(20001201)35:6<593::AID-MPO22>3.0.CO;2-I
Notes: Journal Article Research Support, Non-U.S. Gov't United states Conference: Advances in Neuroblastoma Research, Philadelphia, Pennsylvania, USA, 15 May 2000 to 18 May 2000.
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