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Lookup NU author(s): Dr Emma Bell, Dr Frida Ponthan, Claire Whitworth, Professor Deborah Tweddle, Professor John LunecORCiD, Dr Chris RedfernORCiD
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COX2 is an inducible cyclooxygenase implicated in the metastasis and migration of tumour cells. In neuroblastoma, COX2 expression has been detected in both cell lines and tumours. The treatment of neuroblastoma cells in vitro with celecoxib, a COX2 inhibitor, induces apoptosis. The aim of this study was to investigate the role of COX2 in neuroblastoma tumour biology by creating a cell line in which COX2 could be conditionally expressed. Xenograft studies showed that the conditional expression of COX2 enhanced tumour growth and malignancy. Elevated COX2 expression enhanced the proliferation and migration of neuroblastoma cells in vitro. However, elevated COX2 expression or variation between cell lines did not affect sensitivity to the COX2 inhibitor celecoxib, indicating that celecoxib does not promote cell death through COX2 inhibition. These data show that increased COX2 expression alone can enhance the tumorigenic properties of neuroblastoma cells; however, high levels of COX2 may not be a valid biomarker of sensitivity to non-steroidal anti-inflammatory drugs such as celecoxib.
Author(s): Bell E, Ponthan F, Whitworth C, Tweddle DA, Lunec J, Redfern CPF
Publication type: Article
Publication status: Published
Journal: Clinical & Experimental Metastasis
Year: 2014
Volume: 31
Issue: 6
Pages: 651-659
Print publication date: 01/08/2014
Online publication date: 25/05/2014
Acceptance date: 08/05/2014
ISSN (print): 0262-0898
ISSN (electronic): 1573-7276
Publisher: Springer
URL: http://dx.doi.org/10.1007/s10585-014-9656-3
DOI: 10.1007/s10585-014-9656-3
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