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Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Lookup NU author(s): Professor David YoungORCiD


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P19CL6 are a clonal derivative of P19 embryonal carcinoma cells, a euploid, multipotent mouse cell line, that differentiate efficiently into cardiac myocytes, with spontaneous beating evident within 10 days, following DMSO treatment. Using real-time quantitative RT-PCR we have profiled the expression of the complete matrix metalloproteinase and tissue inhibitor of metalloproteinase gene families during P19CL6 differentiation to cardiac myocytes. The genes subdivide into eight groups based upon their expression profile. Their expression was both qualitatively and quantitatively highly homologous to that seen during mouse heart development.

Publication metadata

Author(s): Young DA, Gavrilov S, Pennington CJ, Nuttall RK, Edwards DR, Kitsis RN, Clark IM

Publication type: Article

Publication status: Published

Journal: Biochemical and Biophysical Research Communications

Year: 2004

Volume: 322

Issue: 3

Pages: 759-65

Print publication date: 24/09/2004

ISSN (print): 0006-291X

ISSN (electronic): 1090-2104

Publisher: Academic Press