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Browsing publications by Professor David Young.

Newcastle AuthorsTitleYearFull text
Dr Matthew Barter
Andrew Butcher
Dr Hui Wang
Dr Dimitra Tsompani
Martin Galler
et al.
HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression2022
Professor David Young
Yao Hao
Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes2022
Krutik Patel
Sharmilla Chandrasegaran
Dr Carole Proctor
Professor David Young
Dr Daryl Shanley
et al.
TimiRGeN: R/Bioconductor package for time series microRNA–mRNA integration and analysis2021
Dr Matthew Barter
Kat Cheung
Julia Falk
Dr Andreas Panagiotopoulos
Professor Stephen O'Brien
et al.
Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation2021
Dan Hayman
Dr Tamara Modebadze
Sarah Charlton
Kat Cheung
Dr Jamie Soul
et al.
Increased hippocampal excitability in miR-324-null mice2021
Dr David Wilkinson
Dr Adrian Falconer
Hua Lin
Kat Cheung
Sarah Charlton
et al.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.2021
Dr Jamie Soul
Dr Matthew Barter
Professor David Young
OATargets: A knowledge base of genes associated with osteoarthritis joint damage in animals2021
Tania Jones
Mohammed Esa
SR Gokul Krishnan
Professor Mark Pearce
Professor David Young
et al.
Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association2021
Dr Jessica Tarn
Sarah Charlton
Andrew Skelton
Dr Matthew Barter
Professor David Young
et al.
Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces2021
Dr Ella Dennis
Robert Jackson
Dr Dimitra Tsompani
Professor David Young
Dr Katarzyna Pirog
et al.
CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development2020
Dr Matthew Barter
Dr Catherine Bui
Kat Cheung
Julia Falk
Dr Rodolfo Gomez
et al.
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions2020
Kat Cheung
Dr Matthew Barter
Julia Falk
Dr Carole Proctor
Dr Louise Reynard
et al.
Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity2020
Dr Sarah Rice
Professor David Young
Professor John Loughlin
Interplay between genetics and epigenetics in osteoarthritis2020
Jose Coelho Lima Junior
Dr Ashfaq Mohammed
Dr Suzanne Cormack
Adnan Ali
Dr Matthew Barter
et al.
Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion2020
Sam Charlton
Kat Cheung
Yao Hao
Dr Jamie Soul
Dr Louise Reynard
et al.
microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs2020
Dr Matthew Barter
Professor David Young
The role of microRNA-3085 in chondrocyte function2020
Kat Cheung
Marjolein Burgers
Professor David Young
Dr Simon Cockell
Dr Louise Reynard
et al.
Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage2019
Bola Ajekigbe
Kat Cheung
Dr Yaobo Xu
Andrew Skelton
Dr Andreas Panagiotopoulos
et al.
Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage2019
Steven Woods
Dr Matthew Barter
Dr Hannah Elliott
Catherine Syddall
Dr Mark Birch
et al.
miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse2019
Professor David Young
Dr Matthew Barter
Dr David Wilkinson
Recent advances in understanding the regulation of metalloproteinases2019
Dr Matthew Barter
Professor David Young
The function of microRNAs in cartilage and osteoarthritis2019
Professor David Young
Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis2017
Dr Matthew Barter
Dr Rodolfo Gomez
Kat Cheung
Andrew Skelton
Dr Yaobo Xu
et al.
The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells2017
Dr Matthew Barter
Professor David Young
Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA2016
Dr Matthew Barter
Professor David Young
Identification and characteriszation of MIR-3085 in chondrocytes2016
Professor David Young
Identification of serum snornas as biomarkers of musculoskeletal ageing and disease2016
Dr Matthew Barter
Kat Cheung
Dr Yaobo Xu
Andrew Skelton
Professor David Young
et al.
Long noncoding RNA ROCR is essential for chondrogenic differentiation of mesenchymal stem cells2016
Dr Matthew Barter
Professor David Young
MicroRNA-455 targets multiple genes in the WNT signalling pathway2016
Dr Matthew Barter
Professor David Young
MicroRNAs: the role of MicroRNAs in the pathogenesis, detection and treatment of OA2016
Dr Matthew Barter
Professor David Young
The microRNA-29 family in cartilage homeostasis and osteoarthritis2016
Dr Dimitra Tsompani
Dr Matthew Barter
Professor David Young
The role of histone deacetylase 3 in chondrogenesis and osteoarthritis2016
Professor David Young
The role of microRNAs in osteoarthritis and ageing-related functional decline in joint tissue homeostasis2016
Dr Michael Rushton
Professor David Young
Professor John Loughlin
Dr Louise Reynard
Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients2015
Dr Michael Rushton
Professor David Young
Professor John Loughlin
Dr Louise Reynard
Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients2015
Dr Matthew Barter
Maria Tselepi
Dr Rodolfo Gomez
Steven Woods
Dr Graham Smith
et al.
Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p2015
Dr Matthew Barter
Professor David Young
Identification and characterisation of novel MicroRNAs in osteoarthritis2015
Shereen Al-Ali
Dr Simon Cockell
Dr Jessica Tarn
Dr Katherine James
Sarah Bowman
et al.
Identification of Whole Blood Gene Expression Signature in Primary Sjogren's Syndrome Associated Lymphoma2015
Dr Matthew Barter
Dr Rodolfo Gomez
Dr Yaobo Xu
Professor David Young
Long non-coding RNAs in chondrocyte development and cartilage2015
Dr Michael Rushton
Dr Louise Reynard
Professor David Young
Dr Colin Shepherd
Dr Rebecca Darlay
et al.
Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci2015
Dr Michael Rushton
Dr Louise Reynard
Professor David Young
Dr Colin Shepherd
Dr Fiona Gee
et al.
Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk2015
Dr Matthew Barter
Professor David Young
The miR-29 family in osteoarthritis2015
Dr Dimitra Tsompani
Dr Matthew Barter
Emeritus Professor Drew Rowan
Professor David Young
The role of Histone Deacetylase 3 in chondrogenesis and osteoarthritis2015
Harriet Purvis
Dr Amy Anderson
Professor David Young
Professor John Isaacs
Dr Catharien Hilkens
et al.
A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses2014
Dr Michael Rushton
Dr Louise Reynard
Dr Matthew Barter
Dr Kenneth Rankin
Professor David Young
et al.
Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis2014
Dr Michael Rushton
Dr Louise Reynard
Dr Matthew Barter
Ramsay Refaie
Dr Kenneth Rankin
et al.
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis2014
Dr Gary Litherland
Martina Elias
Dr David Wilkinson
Sharon Watson
Professor David Young
et al.
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis2014
Shereen Al-Ali
Dr Simon Cockell
Andrew Skelton
Dr Katherine James
Dr Jessica Tarn
et al.
Identification of Whole Blood Gene Expression Signature in Primary Sjogren's Syndrome Associated Lymphoma2014
Dr Katherine James
Dr Jessica Tarn
Shereen Al-Ali
Dr Jennifer Hallinan
Professor David Young
et al.
Integration of Gene Expression Data with Interaction and Annotation Data Reveals Patterns of Connection Between Primary Sjögren’s Syndrome Associated Genes and Immune Processes2014
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Dr Carole Proctor
Investigating molecular mechanisms of ageing cartilage using computer simulation models2014
Dr Matthew Barter
Dr Yaobo Xu
Professor David Young
Long non coding rnas in osteroarthritis and chondrogenesis2014
Dr Matthew Barter
Professor David Young
Methods for the identification of microRNA-455 targets2014
Professor David Young
Emeritus Professor Drew Rowan
Xin Xu
Emeritus Professor Tim Cawston
Dr Carole Proctor
et al.
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage2014
Dr Marta Radwan
Dr David Wilkinson
Dr Auriane Destrument
Sarah Charlton
Dr Matthew Barter
et al.
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination2014
Dr Matthew Barter
Professor David Young
The microRNA-29 family in osteoarthritis2014
Emeritus Professor Tim Cawston
Professor David Young
Emeritus Professor Drew Rowan
Tissue destruction and repair2014
Dr Jessica Tarn
Dr Simon Cockell
Dr Colin Gillespie
Shereen Al-Ali
Dr Katherine James
et al.
Whole Blood microRNA Signature for Primary Sjogren's Syndrome-Related Lymphoma2014
Dr Matthew Barter
Professor David Young
Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis2013
Dr Matthew Barter
Professor David Young
Identification and characterisation of novel microRNAS ivolved in osteoarthritis2013
Dr Marta Radwan
Christos Gavriilidis
Professor John Robinson
Emeritus Professor Drew Rowan
Professor David Young
et al.
Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes2013
Christos Gavriilidis
Dr Satomi Miwa
Professor Thomas von Zglinicki
Professor Robert Taylor
Professor David Young
et al.
Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 22013
Professor David Young
More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis2013
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs1433832013
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Gillian Wilson
Dr Catharien Hilkens
et al.
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease2012
Dr Hui Wang
Professor David Young
Emeritus Professor Tim Cawston
Age-related knee joint cartilage changes in mice2012
Dr Catherine Bui
Dr Matthew Barter
Jenny Scott
Martin Galler
Dr Louise Reynard
et al.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis2012
Dr Hui Wang
Professor David Young
Emeritus Professor Tim Cawston
Cartilage degradation, expression of mmp-13 and oxidation markers increase with age in the knee joints of aged mice2012
Yaobo Xu
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
et al.
Comparison of osteoarthritis and normal hip cartilage transcriptomes using RNA-seq reveals new candidate gene targets and associated pathways2012
Dr Matthew Barter
Dr Catherine Bui
Professor David Young
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs2012
Dr Catherine Bui
Dr Matthew Barter
Professor David Young
Epigenetic regulation of the MMP13 promoter depends on a single CpG site demethylation in human articular chondrocytes2012
Professor David Young
Dr Matthew Barter
Dr Catherine Bui
Epigenetics: marks for future OA research?2012
Dr Matthew Barter
Ellen Rumsby
Andrew Butcher
Professor David Young
Histone deacetylase 6 (HDAC6) is essential for chondrocyte NF-kappa B signalling and MMP expression2012
Dr Hannah Elliott
Dr Matthew Barter
Professor David Young
Identification and characterisation of micrornas involved in chondrocyte differentiation and osteoarthritis2012
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
Dr Mauro Santibanez Koref
et al.
Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA2012
Yaobo Xu
Dr Matthew Barter
Dr Daniel Swan
Dr Kenneth Rankin
Emeritus Professor Drew Rowan
et al.
Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA2012
Dr Marta Radwan
Emeritus Professor Drew Rowan
Professor John Robinson
Emeritus Professor Tim Cawston
Professor David Young
et al.
Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression2012
Dr Gary Litherland
Madona Elias
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Professor David Young
et al.
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases2012
Christos Gavriilidis
Professor Robert Taylor
Professor David Young
Mitochondrial dysfunction and oxidative damage in osteoarthritis2012
Dr Jessica Tarn
Professor David Young
Dr Dennis Lendrem
Christine Downie
Heather Foggo
et al.
Serum cytokine and chemokine profiling in primary Sj ögren's syndrome Normal 0 false false false EN-GB X-NONE X-NONE2012
Jessica Tarn
Andini Natasari
Sheryl Mitchell
Dr Dennis Lendrem
Christine Downie
et al.
Soluble molecule profiling and network analysis of primary Sjogren's syndrome patient serum2012
Dr Hannah Elliott
Dr Matthew Barter
Professor David Young
The expression and function of microRNAs in chondrogenesis and osteoarthritis2012
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs1433832012
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS1433832012
Professor David Young
Dr Catherine Bui
Dr Matthew Barter
Understanding CpG methylation in the context of osteoarthritis2012
Dr Arthur Pratt
Dr Sarah Richardson
Gillian Wilson
Dr Catharien Hilkens
Professor David Young
et al.
A Transcriptional Profile Present in CD4+T-Cells of Patients with Undifferentiated Arthritis Predicts the Future Development of Seronegative Rheumatoid Arthritis and Implicates IL-6 in Disease Evolution2011
Dr Louise Reynard
Dr Catherine Bui
Professor David Young
Professor John Loughlin
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation2011
Steven Woods
Dr Matthew Barter
Helen Elliott
Catherine Syddall
Dr Mark Birch
et al.
miR324-5p in osteoarthritis and indian hedgehog signalling2011
Catherine Syddall
Dr Mark Birch
Professor David Young
miR324-5p is increased in end-stage osteoarthritic cartilage and regulates hedgehog signalling2011
Dr Marta Radwan
Emeritus Professor Drew Rowan
Professor John Robinson
Emeritus Professor Tim Cawston
Professor David Young
et al.
Pattern recognition receptors in osteoarthritic cartilage2011
Professor David Young
Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes2010
Dr Matthew Barter
Leon Pybus
Dr Gary Litherland
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes2010
Professor David Young
Identification and characterisation of micrornas involved in chondrocyte differentiation and osteoarthritis2010
Dr Hui Wang
Emeritus Professor Tim Cawston
Dr Gary Litherland
Madona Elias
Emeritus Professor Drew Rowan
et al.
Leptin produced by joint white adipose tissue induces cartilage degradation by up-regulation and activation of matrix metalloproteinases2010
Dr Matthew Barter
Dr Rachel Lakey
Dr Jonathan Catterall
Emeritus Professor Tim Cawston
Professor David Young
et al.
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation2010
Dr Gary Litherland
Dr Matthew Jefferson
Dr Matthew Barter
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis2010
Dr Jenny Milner
Amit Patel
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
et al.
Matriptase is a novel initiator of cartilage matrix resorptionm in osteoarthritis2010
Steven Woods
Catherine Syddall
Dr Mark Birch
Professor David Young
miR324-5p is increased in end-stage osteoarthritic cartilage and regulates hedgehog signalling2010
Professor David Young
MMP28 gene expression is regulated by Sp1 transcription factor acetylation2010
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Dr Catharien Hilkens
Professor David Young
et al.
Peripheral Blood CD4 T Cell Gene Expression Profiles as Predictive Biomarkers in Early Arthritis2010
Emeritus Professor Tim Cawston
Professor David Young
Proteinases involved in matrix turnover during cartilage and bone breakdown2010
Jenny Scott
Professor Robert Taylor
Professor David Young
Superoxide dismutase 2 downregulation and mitochondria respiration in osteoarthritis2010
Jenny Scott
Christos Gavriilidis
Emeritus Professor Thomas Kirkwood
Professor Robert Taylor
Professor David Young
et al.
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease2010
Dr Arthur Pratt
Dr Daniel Swan
Professor David Young
Dr Catharien Hilkens
Professor John Isaacs
et al.
A High-Throughput Transcriptomics Approach to Biomarker Discover in Early Arthritis2009
Emeritus Professor Thomas Kirkwood
Professor David Young
Investigating superoxide dismutase expression in cartilage and a potential role in osteoarthritis2009
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Lithium inhibits cartilage degradation and MMP production induced by pro-inflammatory cytokines2009
Dr Min Hong
Professor Andrew Gennery
Professor Andrew Cant
Dr Mario Abinun
Professor David Young
et al.
Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy2009
Professor David Young
Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes2008
Dr Gary Litherland
Dr Matthew Barter
Emeritus Professor Tim Cawston
Professor John Robinson
Emeritus Professor Drew Rowan
et al.
Differential Toll-like receptor-dependent collagenase expression in chondrocytes2008
Emeritus Professor Thomas Kirkwood
Professor David Young
Epigenetic regulation of metalloproteinases and inhibitors in osteoarthritis2008
Dr Gary Litherland
Dr Craig Dixon
Dr Rachel Lakey
Tim Robson
David Jones
et al.
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent2008
Professor David Young
Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression2007
Professor David Young
Acetylation regulates expression of the MMP28 gene2007
Emeritus Professor Drew Rowan
Professor David Young
Collagenase gene regulation by pro-inflammatory cytokines in cartilage2007
Emeritus Professor Tim Cawston
Emeritus Professor Thomas Kirkwood
Professor David Young
Investigating SOD2 gene expression and regulation in osteoarthritic cartilage2007
Dr Matthew Barter
Emeritus Professor Tim Cawston
Professor David Young
Downregulation of ADAM12 expression by histone deacetylase inhibitors2006
Dr Jenny Milner
Professor David Young
David Jones
Dr Emma Barksby
Dr Angela Patterson
et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis2006
Dr Jenny Milner
Professor David Jones
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis2006
Dr Jenny Milner
Professor David Young
David Jones
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Fibroblast-activation protein-alpha is expressed by chondrocytes following a proinflammatory stimulus and is elevated in osteoarthritis2006
Emeritus Professor Tim Cawston
Professor David Young
Inhibition of proteolytic activity involved in cartilage breakdown2006
Dr Jenny Milner
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
Professor David Young
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis2006
Professor David Young
Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling2006
Professor David Young
Emeritus Professor Tim Cawston
Acetylation in the control of metalloproteinase expression2005
Professor David Young
Differential effects of histone deacetylase inhibitors on phorbol ester- and TGFbeta- 1 induced Timp-1 gene expression2005
Professor David Young
Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-β1 induced murine tissue inhibitor of metalloproteinases-1 gene expression2005
Professor David Young
Dr Rachel Lakey
David Jones
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption2005
Professor David Young
Dr Rachel Lakey
Professor David Jones
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption2005
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
OM in combination with TNFalpha induces a chondrocyte membrane associated aggrecanase2005
Dr Emma Barksby
Professor David Young
Emeritus Professor Tim Cawston
Emeritus Professor Drew Rowan
Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or-22005
Professor David Young
Dr Rachel Lakey
David Jones
Emeritus Professor Tim Cawston
Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane-associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -22005
Professor David Young
Analysis of cell signaling pathways involved in the expression of metalloproteinases and their inhibitors in fibroblasts2004
Professor David Young
Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes2004
Professor David Young
Expression Profiling of Metalloproteinases and Their Inhibitors in Cartilage2004
Professor David Young
Dr Rachel Lakey
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors are chondroprotective2004
Professor David Young
Emeritus Professor Drew Rowan
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β12003
Professor David Young
TIMP-1 enhancer sequence--real or bacterial?2003
Professor David Young
An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene2002
Professor David Young
Emeritus Professor Drew Rowan
Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors2002
Professor David Young
Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene2002
Professor David Young
The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 12000
Professor David Young
Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced1998