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Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci

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Abstract

Fluorescence in situ hybridization has been used to define deletion breakpoints within chromosome bands 6q16-21 in cases of lymphoid malignancy. Previous evidence suggested that the region might contain a tumour-suppressor gene. Six yeast artificial chromosome probes, each selected using a single marker, were localized to 6q16-21 and the following order was confirmed; D6S330-D6S283-D6S301-D6S447-D6S246-FYN+ ++. Of 32 cases of lymphoid malignancy, 30 showed deletion of D6S246 and, in the two cases in which D6S246 was retained, the adjacent marker, D6S447, was deleted. These observations imply that a region of minimal deletion is located within a 2-megabase segment of 6q21, between D6S447 and D6S246, providing a candidate region for the location of a tumour-suppressor gene.

Publication metadata

Author(s): Sherratt T, Morelli C, Boyle JM, Harrison CJ

Publication type: Article

Publication status: Published

Journal: Chromosome Research

Year: 1997

Volume: 5

Issue: 2

Pages: 118-124

Print publication date: 01/02/1997

ISSN (print): 0967-3849

ISSN (electronic): 1573-6849

Publisher: Springer Netherlands

URL: http://dx.doi.org/10.1023/A:1018418224660

DOI: 10.1023/A:1018418224660

Notes: Journal Article Research Support, Non-U.S. Gov't England an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

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