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Unmet clinical need in autoimmune liver diseases

Lookup NU author(s): Dr Jess Dyson, Professor David Jones



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Dyson JK, Webb G, Hirschfield GM, Lohse A, Beuers U, Lindor K, Jones DEJ

Publication type: Review

Publication status: Published

Journal: Journal of Hepatology

Year: 2015

Volume: 62

Issue: 1

Pages: 208-218

Print publication date: 01/01/2015

Online publication date: 16/09/2014

Acceptance date: 05/09/2014

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641



DOI: 10.1016/j.jhep.2014.09.010