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Health related quality of life in people with advanced chronic liver disease

Lookup NU author(s): Dr James Orr, Tara HomerORCiD, Professor Laura Ternent, Emerita Professor Julia Newton, Emeritus Professor Calum McNeilORCiD, Dr Mark Hudson, Professor David Jones


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Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Orr JG, Homer T, Ternent L, Newton J, McNeil CJ, Hudson M, Jones DEJ

Publication type: Review

Publication status: Published

Journal: Journal of Hepatology

Year: 2014

Volume: 61

Issue: 5

Pages: 1158-1165

Print publication date: 01/11/2014

Online publication date: 07/07/2014

Acceptance date: 30/06/2014

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641



DOI: 10.1016/j.jhep.2014.06.034