Browse by author
Lookup NU author(s): Emeritus Professor Jan Scott
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
ObjectiveWe discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined.MethodWe reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging.ResultsWe report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and the potential utility of neurocognitive, neuroimaging and peripheral biomarkers.ConclusionMost studies to date indicate that globally defined late-stage patients have a worse overall prognosis and poorer response to standard treatment, consistent with patterns for end-stage medical disorders. We believe it is possible at this juncture to speak broadly of early'- and late'-stage bipolar disorder. Next steps require further collaborative efforts to consider the details of preillness onset and intermediary stages, and how many additional stages are optimal.
Author(s): Kapczinski F, Magalhaes PVS, Balanza-Martinez V, Dias VV, Frangou S, Gama CS, Gonzalez-Pinto A, Grande I, Ha K, Kauer-Sant'Anna M, Kunz M, Kupka R, Leboyer M, Lopez-Jaramillo C, Post RM, Rybakowski JK, Scott J, Strejilevitch S, Tohen M, Vazquez G, Yatham L, Vieta E, Berk M
Publication type: Review
Publication status: Published
Journal: Acta Psychiatrica Scandinavica
Year: 2014
Volume: 130
Issue: 5
Pages: 354-363
Print publication date: 01/11/2014
Online publication date: 25/06/2014
ISSN (print): 0001-690X
ISSN (electronic): 1600-0447
Publisher: WILEY-BLACKWELL
URL: http://dx.doi.org/10.1111/acps.12305
DOI: 10.1111/acps.12305
PubMed id: 24961757
