Toggle Main Menu Toggle Search

Open Access padlockePrints

Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function

Lookup NU author(s): Dr Gus Brooks, Professor James Shaw


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


OBJECTIVEIslet graft function is defined by serum C-peptide in a standardized challenge test. We assessed whether urine C-peptide creatinine ratio (UCPCR) sent from home could provide a viable alternative.RESEARCH DESIGN AND METHODSSeventeen islet recipients provided 90-min serum C-peptide (sCP90) and 120-min UCPCR (UCPCR120) samples during 68 interval posttransplant mixed-meal tolerance tests, also posting from home a 120-min postbreakfast UCPCR sample every 2 weeks. UCPCR was compared with a clinical score of islet function, derived from HbA1c and insulin dose.RESULTSUCPCR120 and mean home postmeal UCPCR were strongly correlated with sCP90 (r(s) = 0.73, P < 0.001; and r(s) = 0.73, P < 0.01, respectively). Mean home UCPCR increased with clinical score (r(s) = 0.75; P < 0.001) and with graft function defined both by sCP90 > 200 pmol/L and insulin independence. UCPCR cutoffs to detect insulin independence and poor graft function were sensitive and specific.CONCLUSIONSHome UCPCR provides a valid measure of C-peptide production in islet transplant recipients.

Publication metadata

Author(s): Oram RA, Brooks AM, Forbes S, Eckoldt S, Smith RM, Choudhary P, Rosenthal MJ, Johnson P, Rutter MK, Burling KA, McDonald TJ, Shaw JAM, Hattersley AT

Publication type: Article

Publication status: Published

Journal: Diabetes Care

Year: 2014

Volume: 37

Issue: 6

Pages: 1737-1740

Print publication date: 01/06/2014

Online publication date: 12/03/2014

Acceptance date: 27/01/2014

ISSN (print): 0149-5992

ISSN (electronic): 1935-5548

Publisher: American Diabetes Association


DOI: 10.2337/dc13-1266


Altmetrics provided by Altmetric


Funder referenceFunder name
Diabetes Foundation
Diabetes Research and Wellness Foundation
Juvenile Diabetes Research Foundation
Diabetes UK
National Health Service National Commissioning Group
National Institute for Health Research (NIHR)
Technology Strategy Board grant Prepare for an Evaluation of a Diabetes Interventional Cell Therapy (PrEDICT)
Wellcome Trust
BDA 06/0003362Diabetes UK